Showing 101–125 of 200 documents
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Susan Dorman, MD, Mark Nicol, MBChB, PhD, Mischka Moodley, MBChB, DTM&H, FCPath(Micro)SA
The purpose of this study is to evaluate the accuracy, diagnostic yield, operational performance, and time to diagnosis of a novel lateral-flow urine LAM test in detecting tuberculosis in HIV-infected adults. A secondary study objective is to evaluate the accuracy and diagnostic…
Cecile Magis-Escurra, MD,PhD
Two diagnostic tools for TB screening in high risk groups need additional assessment: the AeoNose™, an 'electronic nose device' for breath sampling, and digital chest X-ray (CXR) with computer aided detection with CAD4TB® software. This study will systematically screen prisoners …
Liverpool School of Tropical Medicine
…ealthworkers will screen for TB using standard sputum-based diagnostics. Group 3: Optimised TB diagnosis, HIV screening and treatment linkage: Participants will receive a high-throughput and high-sensitivity TB screening intervention, in addition to the HIV testing intervention.…
Maastricht University
…erage, low health seeking behavior and lack of efficient TB diagnostics are some of the factors for the low case detection rate in the country \[15\]. Tuberculosis detection is a huge challenge for Ethiopian prisons \[7,16\]. Because of lack of skilled health professionals an…
Susan Dorman, MD, Yukari Manabe, MD
The purpose of this study is to evaluate the accuracy, diagnostic yield, operational performance, and time to diagnosis of a novel lateral-flow urine lipoarabinomannan (LAM) test in detecting tuberculosis in HIV-infected adults. A secondary study objective is to determine the ac…
Freundeskreis Für Internationale Tuberkulosehilfe e.V
Introduction: The large reservoir of tuberculosis infections is a key driver of sustained tuberculosis (TB) incidence. Accurate diagnostic tests are crucial to correctly identify and treat people with TB infection, which is vital to eliminate TB globally. The Cy-TB skin test and …
Stichting Longartsen voor Afrika
…culosis treatment to patients who had negative microbiology diagnostics is still widespread.4-7 However, in the GeneXpert MTB/RIF era, this might no longer be appropriate.8-11 For example, in Zambia, there were an estimated 40000 new tuberculosis cases in 2020 (with 92% pulmonary…
Università Politecnica delle Marche
The main purpose of the present study is to compare the diagnostic yield of different aspiration techniques in Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA) in the diagnosis of hilar/mediastinal adenopathy The role of ultrasound-guided transbronchial needle aspi…
Tom Wingfield, PhD FRCP DTMH DipHIV, Vibol Lem, PhD
…matic individuals, and to reduce dependence on sputum-based diagnostics alone. The research questions being addressed are of direct global relevance. There is currently limited real-world evidence on: how CAD CXR-AI and NPOC tongue swab and sputum swab assays compare as initial …
Stewart Reid, MD
This is a study to evaluate Xpert MTB/RIF as the first-line TB diagnostic test in HIV-infected adults and pediatric patients as a means to obtain faster, more accurate TB diagnosis. This study will evaluate Xpert Mycobacterium Tuberculosis/Rifampicin (MTB/RIF) as the first-line …
Maryline Bonnet, MD, PhD, Olivier Marcy, MD, PhD, Eric Wobudeya, MD, PhD
There is a growing interest for the use of stool samples as an alternative to respiratory samples for the diagnosis of intrathoracic TB in children unable to produce sputum. Unlike respiratory samples, stool samples require processing before molecular testing. Several groups have…
Sarawak General Hospital
Primary Endpoint * To assess the prevalence and diagnostic performance of pre-determined echographic features in predicting the diagnosis of TBE from MPE. * To determine the clinical, pleural fluid and echographic parameters that were different among TBE and MPE and to establish…
Medical University of Warsaw
The development of endobronchial ultrasound (EBUS) and EBUS-guided transbronchial needle aspiration (EBUS-TBNA) has improved the safety and diagnostic accuracy of the mediastinal lymph node (MLN) sampling. Still, in some diseases routine cytological specimens are considered insuf…
Angela Loyse, MD
The DREAMM project is investigating whether the DREAMM interventions (1) Health system strengthening, 2) Co-designed education programs tailored to frontline healthcare workers, 3) Implementation of a diagnostic and treatment algorithm and, 4) Communities of practice in infectiou…
University Hospital, Brest
An increase in the prevalence of infections due to non-tuberculous mycobacteria (NTM) is observed in many countries and recent data suggest the circulation of dominant clones with a possibility of human-to-human contamination. The hypothesis is made that these infections are also…
Francesca Montagnani, PhD, MD
The aim of this project is to analyze the potential contribution of IGRA test QuantiFERON-TB Gold In Tube test (QTF-GIT, Cellestis Limited, Carnegie, Victoria, Australia) in the diagnosis of tuberculosis (TB - active or latent) in pediatric subjects (0 and 17 year)s recently expo…
Anne BOURGARIT, MD, PhD
Tuberculous paradoxical reactions (PR) are immune reactions occurring during the course of antituberculous treatment and leading to a worsening of tuberculous symptoms after an initial improvement. This phenomenon has very extensively studied in HIV infected patients where it cor…
Jeongha Mok
This study aims to compare the diagnostic yield of bronchoalveolar lavage (BAL) using a thick conventional bronchoscope and bronchial washing (BW) using a thin bronchoscope in the diagnosis of pulmonary tuberculosis. In patients with suspected pulmonary tuberculosis (TB), confir…
Qiang Li, Li Jian, Qiquan Zhao
Nonresolving or slowly resolving pneumonia (NRP) poses a diagnostic challenge because infectious and noninfectious etiologies often mimic community-acquired pneumonia on imaging. Endobronchial ultrasound-guided transbronchial lung biopsy (EBUS-TBLB) improves tissue acquisition fo…
Xichao Ou, Guan Liu, Baozhen Peng, Yuehua Li, Hegui Yan, et al.
**BACKGROUND:** Accurate and cost-effective screening for Mycobacterium tuberculosis (Mtb) infection remains a global challenge. While Interferon-γ Release Assays (IGRAs) offer high specificity, their widespread deployment is hindered by high costs and technical complexity.…
Chinese University of Hong Kong
Tuberculosis (TB) is one of the leading causes of infectious disease worldwide. The diagnosis of TB typically relies on microbiological evidence of the presence of Mycobacterium tuberculosis (MTB) or histological features of the host immune response to MTB in the infected organs.…
Keertan Dheda, MBChB, PhD
…ible in different settings and to clarify how the molecular diagnostics should be optimally located. Answering these questions will allow the initiation of ACF programmes in many countries and will contribute critical data to policy makers so that guidelines on ACF can be dissemi…
Gerhard Walzl, PhD, MD
Title: Evaluation of host biomarker-based point-of-care tests for targeted screening for active TB (Screen TB) Introduction: Tuberculosis (TB) places severe pressure on health care services of the developing world. Despite the introduction of the highly sensitive and specific Ge…
Jérémy Charriot, MD
The study is an evaluation of the diagnostic performance of different tests and their association in order to confirm or exclude active tuberculosis. Background : diagnostic methods to distinguish between latent TB infection (LTBI) and active TB disease remains challenging. Data…
Beijing Hospital
Background: Drug resistant tuberculosis is a serious public health problem that threatens the health of human life and the development of society and economy. At present, the diagnosis of drug-resistant tuberculosis mainly depends on traditional drug susceptibility test. But it …