Showing 76–100 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Fernanda Silveira, MD, David L Paterson, MD
Tuberculosis (TB) is an important cause of morbidity and mortality in organ transplant recipients. Management of tuberculosis in this setting is challenging due to the complexity of diagnosis and the potential toxicity of anti-TB therapy, especially in liver transplant candidates…
Gary Maartens (overall PI), FCP, Eric Goemaere (co-investigator), MBBS, Molebogeng X Rangaka (Lead Investigator), MBChB, Gilles van Cutsem co-investigator), MBBS, Andrew Boulle co-investigator), FCP, et al.
…ether isoniazid can safely (and further) reduce the risk of tuberculosis in HIV infected people receiving HAART. The incidence of Tuberculosis (TB) in poor settlements around Cape Town continues to rise despite highly-active-anti-retroviral therapy (HAART) roll-out and DOTS. In …
Dick Menzies, MD, MSc
Tuberculosis (TB) is spread by airborne transmission from adults with active contiguous TB to children, especially those living in the same household. Once children are exposed and infected they are at very high risk to develop active TB - which can be lethal if not detected and …
Hospital Mutua de Terrassa
In countries with a low incidence of Tuberculosis (TB), the incidence remains higher among the immigrant population than among the autochthonous population beyond the first years after arrival in the host country. In addition, at a pediatric level, most cases are produced in immi…
Keertan Dheda, MBChB, PhD
…consortium (Regional Prospective Observational Research for Tuberculosis), that aims to create a multinational bank with the primary objective of providing specimens and data to RePORT consortia biomarker researchers and their collaborators over the next decade to achieve a bette…
Jae-Joon Yim, MD
…on gamma releasing assay(IGRA) is useful to diagnose latent tuberculosis. However,IGRA responses could show within-subject variability. We wanted to determine long-term IGRA variability in health-care workers who continuously expose to tuberculosis patients. IGRA will be perform…
Thomas B Nutman, M.D.
About 2 billion people worldwide are infected with tuberculosis (TB). Ninety percent of those people have latent TB infection (LTBI). Risk factors like malnutrition, diabetes mellitus (DM), and helminth infection can affect the development of active TB. Researchers want to study …
Andrey S Borisov, MD, MPH, Robert Belknap, MD, Robert Belknap, MD
…l. The trial is conducted in patients diagnosed with latent tuberculosis infection (LTBI) who are recommended for treatment. The primary objective is to evaluate adherence to a three-month (12-dose) regimen of weekly rifapentine and isoniazid (3RPT/INH) given by directly observed…
Angelique Luabeya, MD
…ed in 25 HIV negative subjects, 17 of whom will have Latent Tuberculosis Infection (LTBI) and 8 of whom will not have LTBI at study enrollment. The investigational product is AERAS-456 at a dose of 15 ug of H56 antigen with IC31 500 nmol KLK (15/500), and a dose of 50 ug of H56 a…
Heinke Kunst, MD MSc
…ed Kingdom are more likely to complete treatment for Latent Tuberculosis Infection (LTBI) if they are treated in the community (by General Practitioners/Family Doctors and pharmacists) than in a hospital TB clinic. People with dormant/latent TB (LTBI) have TB bacteria in their b…
Sheba Medical Center
…generation immigrants from countries with high incidence of tuberculosis (above 20 of 100,000) compare to the control native Israelis without a family member who was born in a country with high incidence of tuberculosis. Using study questionnaire IGRA and tuberculin skin test the…
Carina Rolo Silvestre, MD, MSc
Prospective, descriptive study to assess latent tuberculosis infection (LTBI) among healthcare worker (HCW) in a tertiary hospital in a low-risk area. identification and treatment of LTBI can substantially reduce the risk of development of disease and are important TB control str…
Haoxin Xu, Jingyu Zhou, Qingluan Yang, Yixuan Yang, Feiran Zhou, et al.
… the higher specificity and reliability of detecting latent tuberculosis (TB) infection, Mycobacterium tuberculosis-specific interferon (IFN)-γ release assays do not perform satisfactorily in predicting the risk of active TB (ATB) development. It is crucial to identify new …
Pinki Bhatt, MD
…tine and Vitamin B6 in renal transplant candidates. Latent tuberculosis infection (LTBI) or inactive tuberculosis, is a common disease found in patients with end-stage renal disease (ESRD) who are being considered for renal transplant (RT). Approximately 5-15% of patients with L…
Sung-Han Kim, MD
….e. Quantiferon-Gold In-Tube assay) for diagnosis of latent tuberculosis infection (LTBI) in bone marrow transplant recipients. For this purpose, the investigators enrolled bone marrow transplant recipients and observed the developement of tuberculosis after the transplantation. …
Christian Wejse, MD PHD
…ntrolled trial comparing compliance to treatment for latent tuberculosis infection in socially marginalised citizens. Participants will be randomized to either daily isoniazid for 6 months or weekly rifapentine and isoniazid as directly observed therapy for twelve weeks. Eligibl…
Lourdes Garcia-Garcia, MD, Jose Sifuentes-Osornio, MD, Alfredo Ponce-de-Leon, MD, Eduardo Sada-Diaz, MD, Martha Torres-Rojas, MD
…this study is to study the effect that treatment of dormant tuberculosis infection has on the immunological system. We expect to observe an impact over the production of cytokines by peripheral white blood cells which may be useful to know if treatment has been effective. As pa…
André S Nell, MD, Pere Joan Cardona, MD, PhD
… RUTI®. RUTI is a therapeutic vaccine made from virulent M.tuberculosis bacteria, grown in stressful conditions, fragmented, detoxified, heat inactivated (FCMtb) and liposomed. RUTI provides a strong humoral and cellular immune response against antigens from active growing and l…
Surendra K Sharma, M.D., Ph.D
…Treg cells) impair the protective T cell response against M.tuberculosis and disrupts LTBI, thus facilitates faster progression and development of severe forms of clinical TB in HIV-TB co-infection. During the natural course of HIV disease, emergence of opportunistic infection n…
Chin-Chung Shu, MD
…differentiate potential of active TB from LTBI Background: Tuberculosis (TB) remains the most important infectious disease worldwide. For controlling TB, the important strategy includes not only adequate anti-tuberculous treatment but also well control of latent TB infection (LT…
Sang-Heon Kim, MD, PhD.
…rs aim to study the prevalence of adverse reactions of anti-tuberculosis (TB) drugs in latent tuberculosis infection (LTBI), and determine the risk factors of anti-TB drug-related toxicity in LTBI in Korean health care workers(HCWs). Further study details as provided by Hanyang …
Alice Turner
…vitamin D supplementation in patients with active or latent tuberculosis in which active disease patients take 100000units of vitamin D every 8 weeks during their tuberculosis treatment. Genotyping for relevant vitamin D pathway polymorphisms will be carried out and related to cl…
Weijian Liu, Nuo Xu, Wei Li, Wen Yao Mak, Tian He, et al.
…ety of 4-week daily rifapentine-isoniazid regimen in latent tuberculosis for Chinese children, and to provide paediatric-specific evidence for extrapolating adult dosing strategies to children. **METHODS:** An open-label, prospective, single-arm clinical trial was conducted amon…
Kent Hospital, Rhode Island
…s' knowledge, attitudinal, and skill gaps related to latent tuberculosis infection (LTBI) testing and treatment. The gaps identified will inform the design of a survey and telementoring educational program (tuberculosis (TB) infection ECHO course). The EMR data query will further…
National Taiwan University Hospital
…l follow up in comparing with QuantiFERON-TB Gold In-tube. Tuberculosis (TB) remains one of the most important infectious diseases worldwide. According to the World Health Organization (WHO) estimates, there were 9 million new TB cases and 1.5 million related deaths in 2013. Fut…