Showing 51–71 of 71 documents
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Felicia C Chow, MD
…hout linezolid (LZD) for the first 4 weeks of treatment for Tuberculosis Meningitis (TBM) at Masaka Regional Referral Hospital in Uganda. Initial randomization will be to high (35 mg/kg/day) versus standard (10 mg/kg/day) dose oral rifampin for the first 4 weeks of intensive ther…
Guy Thwaites, MD, PhD, Nguyen H Phu, MD, PhD
…nd adjunctive dexamethasone, according to Viet Nam National Tuberculosis Programme guidelines. Participants will be stratified by Medical Research Council UK disease severity grade, and randomized at enrollment to one of three study arms (1:1:1 ratio). Patients will be admitted t…
Beijing Chest Hospital
Tuberculous meningitis (TBM) is the most lethal form of tuberculosis (TB). While anti-TB regimens remain the cornerstone of treatment, spinal injection of dexamethasone is considered a potentially effective adjuvant therapy. However, its impact on mortality and disability remains…
Rovina Ruslami, M.D., PhD
Tuberculous meningitis (TBM) is the most severe form of tuberculosis infection with high mortality. Current treatment regimens are not based on clinical trials. Rifampicin is a key drug for TBM, but its penetration into the brain is limited, suggesting that a higher dose may be m…
All India Institute of Medical Sciences
…inical features. * Participants will follow treatment for tuberculosis as per the treating physician's discretion in terms of anti-tubercular therapy, anti-seizure medication therapy, duration and dose of corticosteroids and steroid sparing agents. * Data collection and analy…
Ahmad R Ganiem, MD, PhD
Tuberculosis meningitis (TBM) is the most severe manifestation of TB, resulting in death or neurological disability in up to 50% of affected patients, despite antibacterial treatment. This TBM treatment follows the model for pulmonary TB by using the same first-line TB drugs (a c…
Jose M Calderin, Sean Wasserman, Juan Eduardo Resendiz-Galvan, Noha Abdelgawad, Angharad Davis, et al.
…ere consistent with previously reported values in pulmonary tuberculosis, even when co-administered with high-dose rifampicin.
National Institute of Allergy and Infectious Diseases (NIAID)
…lth Organization (WHO) standard of care (SOC) treatment for tuberculosis meningitis (TBM). Rationale: TBM is a devastating illness with high risk of mortality and severe neurologic morbidity. Although recent data suggest that significant dose increases in RIF may improve outcome…
Ethel M Weld, MD
…individuals with HIV-1 receiving rifampin-based TB therapy Tuberculosis (TB) is the most common cause of death in people with HIV worldwide. Among patients with HIV, the incidence of TB per year is about 5-10%. The two diseases are now always treated concurrently in co-infected …
Dvijen Purohit, Rob van Wijk, Paddy Kafeero, Freddie Kibengo, Matthew Zimmerman, et al.
…berculous meningitis (TBM), a severe form of extrapulmonary tuberculosis, requires sustained therapeutic drug concentrations in the central nervous system (CNS). Linezolid is a promising treatment for TBM due to excellent CNS penetration and bactericidal activity against. However…
Nilesh Bhatt, MD, MMED
…study with a follow up time of at least 6 months, up to 300 tuberculosis (TB) patients or TB suspects will be screened for TB using the Xpert MTB/RIF assay along with standard smear microscopy after Ziehl-Neelsen staining at the TB health clinic located at Mavalane health center.…
Angela Loyse, MD
…crobiological detection and treatment of cryptococcosis and tuberculosis in the five study sites. The aim is to reduce the time from participant presentation to diagnostic testing and administration of effective, microbiologically-driven treatment. As part of the implementation o…
Estee Torok, MD
…llected will focus on survival, neurological disability and tuberculosis relapse. Data will be collected in individual case record forms and entered into a computer database.
Meena Chandu, Rohit Bhatia, Manish Modi, Ritu Shree, Imnameren Longkumer, et al.
**BACKGROUND:** Cerebral infarction is a frequent and serious complication of tuberculous meningitis (TBM), contributing substantially to morbidity and mortality. Moreover, studies on infarct patterns and associated factors/predictors remain limited in TBM. ACT-TBM trial (Aspirin…
Hui Bu
The study aimed to evaluate the relationships between the gene polymorphisms of leukotriene A4 hydrolase(LTA4H) and Dexamethasone treatment for tuberculous meningitis in Chinese patients.
Joseph Donovan, Nguyen Duc Bang, Huu Khanh Trinh Dong, Dang Trung Nghia Ho, Thi Anh Thu Nguyen, et al.
Adjunctive corticosteroids such as dexamethasone are recommended in tuberculous meningitis treatment, despite modest and heterogeneous survival benefit. Leukotriene A4 hydrolase (LTA4H) genotypes associate with distinct intracerebral inflammatory phenotypes and may determine cort…
Felicia C Chow, Paddy Kafeero, Maria Nakimbugwe, Anthony Ssemaganda, Colman Tayebwa, et al.
**BACKGROUND:** Tuberculous meningitis (TBM)-related deaths occur early, often within weeks after treatment initiation. Enhanced treatment early in the disease course with agents that effectively penetrate the central nervous system may improve outcomes in TBM. **METHODS:** We c…
David B Meya, Fiona V Cresswell, Biyue Dai, Nicole Engen, Kogieleum Naidoo, et al.
**BACKGROUND:** Tuberculous meningitis is often lethal, and many survivors have disabilities despite antimicrobial treatment and adjunctive glucocorticoid therapy. Standard-dose rifampin has limited central nervous system penetration. Whether high-dose rifampin could improve surv…
Jose M Calderin, Juan Eduardo Resendiz-Galvan, Noha Abdelgawad, Angharad Davis, Cari Stek, et al.
**BACKGROUND:** Dexamethasone is recommended as adjunctive therapy for tuberculous meningitis (TBM). Co-administration with rifampicin is expected to reduce dexamethasone exposure in TBM, an effect that may be more pronounced with the higher rifampicin doses currently being evalu…
Rovina Ruslami, M.D., PhD
Tuberculous (TB) meningitis is the most severe manifestation of TB infection, leaving up to 50% of patients dead or neurologically disabled. Current treatment is similar to treatment of lung TB, although penetration of some antibiotics into the brain is poor and the immune-pathol…
Julie Huynh, Chishala Chabala, Suvasini Sharma, Louise Choo, Varinder Singh, et al.
…conditional recommendation that 6 months of intensified antituberculosis therapy (ATT) could be used as an alternative for drug-susceptible TBM. However, this has never been evaluated in a randomised clinical trial. Trials evaluating ATT shortening regimens using high-dose rifamp…