Showing 51–75 of 99 documents
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Steven M Holland, M.D.
…ques has expanded our understanding of the pathogenesis and epidemiology of MTB. Identification of gene mutations that confer antibiotic resistance are being exploited as alternatives to conventional drug susceptibility testing. The natural history of all forms of TB disease (in…
PENTA Foundation
…ohorts within the same region are often similar in terms of epidemiology and treatment approaches), and region is then included as a covariate in the analysis. REGULATORY \& ETHICAL ISSUES COMPLIANCE EPPICC is an observational study with no study-specific interventions beyond th…
Mengiste M Melese, MD, MPH, PhD, Madley J Richard, MD
The purpose of the study is whether the provision of tuberculosis care using volunteer community health workers or self-administered treatment for 7 months is equally effective with the existing 8 months of TB care in public health facilities by health workers. Patient care by vo…
Anuraj H Shankar, D. Sc.
SPHERES is a health service research trial in the Indonesian primary care system designed to improve health system performance using a structured data-driven action model. The intervention empowers district health leaders to make data-informed decisions that will enhance outcomes…
David S Hui, MD
…. The project will provide useful data on the surveillance, epidemiology and public health control of TB with a regional (cross-border) significance.
Adithya Cattamanchi, MD
…y assessment, diagnostics development, laboratory medicine, epidemiology, health economics and mathematical modeling with highly experienced clinical study sites in 10 countries. The Rapid Research in Diagnostics Development for TB Network (R2D2 TB Network) study seeks to identi…
Johanna Åhsberg, MD, Isik Somuncu Johansen, Prof, Margaret Lartey, Prof, Stephanie Bjerrum, MD, Åse Bengaard Andersen, Prof, et al.
…d overall early mortality at 8 weeks. The HIV-associated TB epidemiology including genotypic analyses of M. tuberculosis isolates obtained through the main study will be described. In sub study A, focused ultrasound of lungs, heart and abdomen will be performed in a sub cohort of…
Grant Theron, PhD
TB is a global health problem and in South Africa rates as the second most important problem in terms of Burden of Disease. There are many reasons for this, among which are diagnostic difficulties, extended treatments, drug resistance and health care provision. This application i…
Chinese University of Hong Kong
Tuberculosis (TB) remains a major global health challenge, affecting over 10 million people annually. Hong Kong carries an intermediate TB burden, with \~3,200 new cases reported yearly. Pulmonary TB (PTB), the most common form, presents diagnostic difficulties. Traditional metho…
Christian Lienhardt
The project aimed to test a strategy for the early detection and prevention of tuberculosis in household contacts of tuberculosis patients in order to reduce the morbidity, mortality and transmission of this disease in Thailand. This strategy will be evaluated in comparison with …
Grant Theron, PhD
The diverse microbial communities in different parts of the human body (microbiome) are important for health but understudied in pulmonary tuberculosis (TB), which is the single biggest infectious cause of death in the world. The investigators will study the site-of-disease micro…
Beijing Hospital
Background: Drug resistant tuberculosis is a serious public health problem that threatens the health of human life and the development of society and economy. At present, the diagnosis of drug-resistant tuberculosis mainly depends on traditional drug susceptibility test. But it …
Nestani Tukvadze
…to recommendations by the WHO and in the light of the local epidemiology\[8\]. Furthermore, introducing a new diagnostic technology might lead to better patient care by shorter time to diagnosis, rather than through specific improved performance characteristics\[9\]. The propose…
Jann-Yuan Wang, MD
… failure of control implies the necessity to reevaluate the epidemiology of Mycobacterium tuberculosis. It is widely thought that most cases of TB are caused by reactivation of a latent infection. Treatment programs have therefore focused on cure rates rather than tracking of add…
Léa DOMITIEN
…pellier University Hospital from 2014 to 2021, to study the epidemiology and bacterial ecology of these infections and to evaluate the effectiveness of the therapeutic strategy and side effects, long-term sequels
Helen McShane, MD and PhD
A Phase I study of the Safety and immunogenicity of MVA85A in healthy Gambian volunteers Study Design: The study is a non-randomized clinical trial. Twelve volunteers will be recruited. They would be given 5x107 pfu of the MVA85A vaccine intradermally. The subjects will be requi…
Grace John-Stewart, MD, PhD
Randomized controlled trial (RCT) of isoniazid (INH) vs. no INH to prevent Mycobacterium tuberculosis infection in HIV-exposed uninfected (HEU) infants. The purpose of this trial is to determine whether isoniazid (INH) reduces the risk of Mycobacterium tuberculosis (MTB) infecti…
J. Lucian Davis, MD
In a previous randomized control trial, the investigators identified gaps in the implementation of tuberculosis (TB) contact investigation at multiple levels of the service delivery cascade. Drawing on prior experiences, the investigators have recently developed a novel strategy …
Maastricht University
Introduction: Finding and successfully treating all tuberculosis (TB) patients is the cornerstone of the Global Strategy to Stop TB. However, many patients in resource-limited countries remain undiagnosed. Prisons are a well-known source of undetected TB. Thus, there is a need to…
Olivier Marcy, MD, PhD, Maryline Bonnet, MD, PhD, Eric Wobudeya, MD, PhD
Despite progress in reducing tuberculosis (TB) incidence and mortality in the past 20 years, TB is a top ten cause of death in children under 5 years worldwide. However, childhood TB remains massively underreported and undiagnosed, mostly because of the challenges in confirming i…
Ludwig Boltzmann Institute for Lung Health
The goal of this non-interventional registry study is to systematically collect epidemiological and clinical data throughout the treatment course to learn about effectiveness of treatments. We will document the natural course of therapy without additional interventions. The main …
Surendra K Sharma, MD, Ph.D
The purpose of the study is to evaluate the efficacy and safety of Nevarapine and Rifampicin vs Efavirenz and Rifampicin in antiretroviral naive patients co-infected with HIV and TB and to investigate whether Rifampicin co-administration in clinical practice leads to a clinically…
Ronald Crystal, MD
Identify a biologic (molecular) basis for the increased susceptibility of cigarette smokers to pulmonary TB (Mtb) by testing the hypothesis that smoking reprograms AM polarization towards a distinct phenotype associated with impaired host defense function against Mtb and that nor…
Xavier ARGEMI, MD
The purpose of this study is to examine the epidemiology of TB MR in Strasbourg and evaluate the second-line anti-tuberculosis treatments effectiveness, and the relevance and adequacy of the treatments with WHO recommendations. During years 2006-2016, all new cases of MDR TB or X…
Linda Gail Bekker, MBChB, FCP, PhD, James McIntyre, MBChB, MRCOG
The purpose of this study is to determine the number of people infected with tuberculosis (TB) in the Masiphumelele Township of Cape Town, South Africa, a community with high rates of TB and HIV. This study will also examine the genetics of TB and the relationships among active T…