Showing 26–50 of 52 documents
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International Centre for Diarrhoeal Disease Research, Bangladesh
…ife following TB recovery Associations between demographic, social, and lifestyle factors and post-TB sequelae Through this observational study, researchers hope to contribute valuable insights into the long-term health challenges faced by TB survivors, particularly among childre…
Degu J Dare, MD, PhD
…dequately adhere to their prescribed regimen due to various social, economic, personal, and healthcare system barriers. However, previous interventions did not adequately consider combined strategies in a way that addressed social, personal, economic, and health system barriers t…
J. Lucian Davis, MD, Achilles Katamba, PhD, Mari Armstrong-Hough, PhD
…implementation trial evaluating a complex, multi-component, social and behavioral intervention designed to normalize the acceptance of HIV testing in the household and increase diagnosis of HIV. An estimated 39 million people worldwide are living with HIV, but nearly half do not…
Bahir Dar University
…hods: self-reported household income loss net of welfare or social assistance payments. This includes the cost that the caregivers bear by contributing their time and in-kind services. Any gain or loss of income reported during each phase or for the entire episode is considered t…
Sema Aytac
…oviding the self-care agency of patients and the cognitive-social adaptation. It has been reported that some problems emerge especially in the TB patients such as the interruption of treatment, forgetting medication (24.5%), side-effects of drugs, (23.3%), symptomatic recovery (1…
Universidade Federal do Rio de Janeiro
…als in three areas or domains: symptoms, activity and psychosocial aspects. Another instrument used to assess quality of life is the Short-Form 36 (SF-36), a generic questionnaire, self-administered or applied by interview, consisting of 36 items that assess the domains: function…
Siyan Yi, PhD, Alvin Teo, MPH
…ed. Limited access to health care, high treatment cost, and social stigma of TB contributed to delayed detection and poor treatment uptake. Other risk factors such as poor living conditions and overcrowding further perpetuated the transmission of TB, which, in turn, leads to soci…
Assistance Publique - Hôpitaux de Paris
…sive national strategic plan for TB and could help identify determinants for unfavorable treatment outcome or loss to follow-up. The healthcare pathway of patients with tuberculosis presents glaring shortcomings with a large proportion of treatment outcomes unknown, including a l…
Maastricht University
…ues, and behavior in educating others who may share similar social backgrounds or life experiences. Prison: A facility that holds convicts who have committed crimes the legal system deems especially serious for more long term sentences. 3.13. Plan for Analysis Collect…
Diane Havlir, MD, Gabriel Chamie, MD, MPH
…d on the PRECEDE framework which outlines the importance of social networks, social influence, and behavior change. The SEARCH-IPT multi-component intervention includes: * A teaching collaborative which will be formed within the randomized clusters of district DHOs and DTLSs to…
JHP Pharmaceuticals LLC
Determine if investigational products and reference standard produce similar responses. Primary: To determine if the 2 investigational products (Aplisol formulated from the new Tuberculin PPD drug substance and the reference standard PPD-S2) produce qualitatively similar respon…
New York State Psychiatric Institute
This hybrid type I effectiveness-implementation trial will increase understanding of the effectiveness and cost-effectiveness of integrating a brief evidence-based treatment for major depressive disorder (MDD) within the tuberculosis (TB) care platform to improve TB and MDD. Find…
J. Lucian Davis, MD
… CHWs and that it will increase self-efficacy and perceived social support among CHWs. Finally, the investigators hypothesize that models evaluating the impact of the user-centered strategy when delivered nationwide will find it cost-effective and able to reduce national TB incid…
Olivier Marcy, Chishala Chabala, Joanna Orne-Gliemann, James Seddon
…luding associated digital tools, and to identify contextual determinants influencing implementation and contribute to improved implementation/adaptations throughout intervention delivery. 3. To assess preferences, acceptability, and perceived feasibility of using the comprehensiv…
Jean William Pape, MD, Patrice Severe, MD, Daniel W. Fitzgerald, MD
Anti-HIV treatment consisting of lamivudine/zidovudine (3TC/ZDV) and efavirenz (EFV) is the current standard of care for initial treatment of HIV in most areas of the world. The purpose of this study is to determine the best time to start this anti-HIV treatment in treatment-naiv…
Brittney J van de Water, PhD
… into routine management systems, and identify clinic-level determinants of successful SAIA-TB implementation. Recurrent measurement of structural readiness and implementation dose (as a function of quality and quantity) at the clinic level will inform guidance on essential struc…
Xavier Mariette, Pr
Tuberculosis is a current infection during anti TNF therapy. After infectious contact, some patients will develop tuberculosis and some will only be infected without symptoms, they have Latent Tuberculosis Infection (LTBI) wich can reactivate later. In order to prevent this tuber…
Gustavo E Velásquez, MD, MPH
PRISM-TB is an international, seamless, multicenter, open-label, randomized, controlled, pragmatic, stratified medicine, treatment shortening, multi-arm multi-stage (MAMS), noninferiority Phase 2/3 clinical trial for fluoroquinolone-susceptible multidrug-resistant/rifampin-resist…
Rina La Distia Nora
The aim of this study is to determine the proportion of clinical improvement, the score changing of type 1 interferon selected gene expression, and analysis of transcriptomics profiling in patients with idiopathic uveitis positive IGRA before and after receiving Anti-Tuberculosis…
Yael Hirsch-Moverman, PhD
…ervention that addresses programmatic, structural and psychosocial barriers to contact tracing, screening, and IPT for child contacts of TB patients, with the ultimate goal of improving health outcomes among children in Lesotho. The study is a two-arm cluster randomized trial, ra…
Anne BOURGARIT, MD, PhD
Tuberculous paradoxical reactions (PR) are immune reactions occurring during the course of antituberculous treatment and leading to a worsening of tuberculous symptoms after an initial improvement. This phenomenon has very extensively studied in HIV infected patients where it cor…
Kevin P Fennelly, M.D.
Background: Tuberculosis (TB) is a lung disease. It is caused by inhaling a type of airborne bacterium. Tuberculin Purified Protein Derivative (PPD) is used to test for TB exposure. It is usually injected under a person s skin. In this study, it will be applied in the lung. Obj…
Taipei Medical University WanFang Hospital
To assess outcome of treatment and safety among patients with rifampicin-resistant isoniazid-susceptible pulmonary tuberculosis treated with a novel regimen consisting of isoniazid, bedaquiline, and moxifloxacin throughout for 6 months, supplemented by pyrazinamide for the initia…
Jing-Xin Li, PhD, Li-mei Zhu
This is a randomized, double-blind, parallel-controlled study, for evaluation of safety and immunogenicity of three doses of an inactivated COVID-19 vaccine (CoronaVac) in pulmonary tuberculosis patients aged 18-75 years. 200 tuberculosis patients and 40 healthy adults aged 18-75…
BioNTech Responsible Person
This is a two-part randomized, placebo-controlled, observer-blind, safety and dose-finding Phase Ib/IIa study. This study will evaluate up to four dose levels of the BNT164 investigational vaccines (BNT164a1 and BNT164b1) to select a safe and tolerable dose in a three-dose schedu…