Showing 26–50 of 72 documents
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Carolyn Bolton, MBBCh, Mutsawashe Bwakura-Dangarembizi, MD, Ellen Gould Chadwick, MD
…actors make EFV an attractive agent for use in HIV-infected pediatric patients with and without TB coinfection. This study will evaluate the safety, tolerance, and pharmacokinetics (PKs) of EFV when administered as opened capsules to pediatric patients younger than 3 years of age…
Gonzalo G Alvarez, MD
…ent for LTBI.(1) These findings were also replicated in the pediatric population through a pediatric cohort (n=905 eligible participants) nested within the multi-centered international randomized controlled trial with children between ages 2-17 treated with 3HP compared to the IN…
Roberto J Pires Neto
…spected tuberculosis hospitalized in the units of Adult and Pediatric Clinics and in the Critical Care Unit in a general hospital in Fortaleza-CE.
Scott K Heysell, MD
…s in severe TB syndromes (including multidrug-resistant TB, pediatric TB, TB sepsis and TB meningitis) from diverse geographies (including Tanzania, Uganda, Bangladesh, and Siberia) and correlate these findings to TB treatment outcome (TB treatment failure: death/ default/ relaps…
Kelly Dooley, MD,PhD
…rocognitive outcomes by treatment group, as measured by the Pediatric Modified Rankin Score (MRS) and the Mullen Scales of Early Learning (MSEL), respectively. Open-label, randomized clinical trial in three treatment groups. Patients with probable or definite TB meningitis (TBM)…
Holly Rawizza, MD, MPH
…rs to \<6 years. Children will be recruited from two large pediatric HIV clinics in Nigeria. Children in this study will receive HIV/TB cotreatment that is considered standard of care consisting of DTG twice daily during rifampicin (RIF)-containing TB treatment. For this portion…
Michael Marmor
…nel. Natural history and impact on HIV disease in adult and pediatric populations were assessed by interviews, clinical screening and laboratory measures. Drug sensitivity testing and RFLP typing of specimens from the two populations were conducted, respectively, at the Bellevue …
Helen M McIlleron, PhD, Heather Zar, PhD
… when applying the 2010 WHO/IUATLD dosing guidelines across pediatric populations (0-12 years of age, HIV infected and uninfected, and with varied nutritional status) in Cape Town, South Africa and Blantyre, Malawi. 2. To evaluate an 8-hourly weight band-based dosing strategy for…
Olivier Marcy, MD, PhD, Maryline Bonnet, MD, PhD, Eric Wobudeya, MD, PhD
…eloped the PAANTHER algorithm. The ANRS 12229 PAANTHER 01 (Pediatric Asian African Network for Tuberculosis and HIV Research) study, which enrolled 438 HIV-infected children of median age 7.3 (IQR: 3.3 - 9.7) years with presumptive TB in four countries (Burkina Faso, Cameroon, C…
Léa DOMITIEN
…ations for prosthesis infections in adults. However, in the pediatric population, this type of infection is rarer and their management less well codified. The aim of this retrospective and descriptive monocentric study is to identify all osteoarticular infections in children und…
Greta L Becker, MD, Eric Wobudeya, MBChB, MMED, MSc
… whether this intervention can be feasibly implemented in a pediatric population in a low-resource context and to inform the design of a future randomized controlled trial.
Nicole Salazar-Austin, Silvia Cohn, Bareng A S Nonyane, Christiaan Mulder, Fiseha Mulatu, et al.
…TPT has the potential to substantially reduce the burden of pediatric TB in Ethiopia and elsewhere. **CLINICAL TRIALS REGISTRATION:** NCT04369326.
Bahir Dar University
…ces. Informed consent for adult participants and assent for pediatrics participants will be obtained before data collection started. The purpose of the study will be communicated and permission will be obtained from the respected officials; the regional health bureau, respected z…
University of Virginia
…re conversion and weight change are stratified by age given pediatric populations are more likely to be culture negative and clinically diagnosed with weight gain a central measurement of treatment response. Safety of dose adjustment strategy parameters include clinical adverse e…
Richard A. Oberhelman, MD
… evaluate novel approaches to the diagnosis of AIDS-related pediatric TB in a hyperendemic setting using rapid, cost-effective Mtb culture and susceptibility methods based on direct microscopic observation techniques. This study will utilize alternative noninvasive Mtb tests that…
National Taiwan University Hospital
…yopreserved donor aortic tissue patches to repair and treat pediatric patients with end-stage, life-threatening or severely disabling tracheal diseases who have not responded to conventional conservative therapies or lack sufficient native tracheal tissue for tracheal defect reco…
University of Virginia
…he End TB Strategy. A simple, inexpensive test to identify pediatric and adult TB patients with low drug exposures, available at the point-of-care at the time of the patient encounter, would support clinical decision-making. The performance of therapeutic drug monitoring require…
Worku Nigussa, MD
…, respectively, CAD software and stool Xpert MTB/RIF in the pediatric population and adult population are needed. The study will be carried out in at St. Luke Catholic Hospital, Wolisso, in Ethiopia. St. Luke Catholic Hospital is the referral Hospital in Southwest Shoa zone, Or…
Kilimanjaro Clinical Research Institute
…untries, Tanzania being one of them. The enormous burden of pediatric TB in these countries is due to the TB epidemic amongst adults and the simultaneous HIV pandemic and a child less than 14 years of age whether HIV infected or not is at a high risk of developing the disease. Su…
Lianda Tamara, MD,Paed
…gnosis of the tuberculosis case was based on The Indonesian Pediatric Tuberculosis Scoring System. It consists of history taking and laboratory findings that support tuberculosis common symptoms such as household contact, prolonged fever more than two weeks, non-remitting cough m…
Molly F. Franke, ScD
… of Mtb DNA purification, extraction, and (2) use in future pediatric TB diagnostic research.
Nayab shahid, MS-PT
…en used separately, their combined effect on the therapy of pediatric tuberculosis has not been fully investigated. The aim of this study is to investigate the Effect of the Active cycle of breathing technique with and without balloon blowing therapy on sputum secretion, dyspnea …
Hospital Mutua de Terrassa
… years after arrival in the host country. In addition, at a pediatric level, most cases are produced in immigrant children and the children of immigrants. This persistence of a greater incidence in the immigrant population might, in part, be explained by the increase in exposure …
Chiang Mai University
…mended to use Xpert MTB/RIF assay to diagnose pulmonary TB, pediatrics TB, extra pulmonary TB and rifampicin resistance. However, the data of accuracy in diagnosis of TBM is still lacking. This study aimed to find out the diagnostic performance of Xpert MTB/RIF assay for the diag…
Jyoti S. Mathad, MD, MSc
The purpose of this study was to evaluate the pharmacokinetics (PK), tolerability, and safety of once-weekly doses of rifapentine (RPT) and isoniazid (INH) in HIV-1-infected and HIV-1-uninfected pregnant and postpartum women with latent tuberculosis (TB). TB is a major cause of …