Showing 26–50 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Jacobuss de Waard, PhD.
The purpose of this study is to determine the diagnostic utility of the device 'Electronic Nose' for Pleural TB, which is a Extra pulmonary TB form, compared with pleural biopsy, the current gold standard. The aim of the study is to determine the diagnostic utility of the device…
Shen Gwan Han, MD
Pulmonary tuberculosis is one of the most important infectious diseases in human with high mortality. Early diagnosis followed by antibiotic treatment is the only way for control of the disease. However, most of commercial tuberculosis diagnostic kits are of moderate sensitivity…
Edouard Tuaillon, MD, PhD, Chipepo Kankasa, MD, PhD, Philippe Van de Perre, MD, PhD, Nicolas Nagot, MD, PhD
Diagnosis of tuberculosis (TB)in young children is a challenge due to atypical non-specific symptoms, difficulty to expectorate mucus, paucibacillary nature of pulmonary TB and low sensitivity of available diagnostic tools. This project aims at evaluating two innovative immunolo…
Wei-Chang Huang, Yi-Wen Huang, Chih-Bin Lin, Shun-Tien Chien, Chih-Hsin Lee, et al.
Nucleic acid amplification tests (NAATs) were performed selectively as an initial diagnostic test for pulmonary tuberculosis (TB) in Taiwan. We assessed whether expanded use of Xpert MTB/RIF assay as an initial diagnostic test made positive contribution to the management of TB. P…
Susan Swindells, MBBS, Srikanth Tripathy, MBBS
An estimated 3 million HIV-infected individuals will enter programs for antiretroviral (ARV) treatment in the coming year, with projected rates of requirement for ARV therapy extending to more than 10 million in sub-Saharan Africa, southeastern Asia, and Latin America in the comi…
Wang Ye Prof
The global incidence rate and mortality of tuberculosis (TB) pose a challenge to achieving the goals set out in the tuberculosis eradication strategy and the SDGs by 2030. At present, timely and accessible early detection methods for tuberculosis are still a major obstacle. In th…
Heiman F Wertheim, PhD
Detection of M. tuberculosis in clinical specimens of children has a low sensitivity because specimens are either difficult to collect or contain low levels of M. tuberculosis. Diagnostic criteria are non-specific and culture confirmation is challenging, as sputum samples are not…
Andreas Diacon, MD, Henrik Aggerbeck, M.Sc.
…C-Tb test. The TESEC-05 trial is an open comparison of the diagnostics performance of C-Tb compared to the QuantiFERON®-TB Gold In-Tube, in combination with a double-blind randomized split-body safety assessment of C-Tb versus to 2 T.U. Tuberculin PPD RT23 SSI. The trial is a m…
Saima Bashir, Lelisa Fekadu Assebe, Akash Malhotra, Délio Elísio, Antonio Machiana, et al.
**BACKGROUND:** In low- and middle-income countries (LMICs), tuberculosis (TB) regained its status as the leading cause of death from a single infectious agent in 2023, surpassing COVID-19. Rapid and accurate diagnosis is critical, with decentralised diagnostic strategies offerin…
Weicong Ren, Mengjie Yang, You Zhou, Yinghui Yang, Haoran Li, et al.
**BACKGROUND:** Tuberculous pleurisy (TP), a predominant form of extrapulmonary tuberculosis, presents significant diagnostic challenges attributable to the paucibacillary nature of pleural effusion (PE) specimens. Cell-free Mycobacterium tuberculosis (MTB) DNA in PE represents a…
China-Japan Friendship Hospital
The goal of this clinical trial is to compare the diagnostic efficacy and safety of Endobronchial Ultrasound-guided Transbronchial Mediastinal Cryobiopsy (EBUS-TBMC) versus standard EBUS-guided Transbronchial Needle Aspiration (EBUS-TBNA) in adult patients with suspected mediasti…
Xuelin Yang, Hao Zhang, Wenjie Jiang, You Xin, Zhenwei Dai, et al.
**INTRODUCTION:** Tuberculosis (TB) remains a globally concerning infectious disease, and significant challenges persist in attaining the 2030 targets set by the WHO. With the rapid advancements in computer-aided detection (CAD) technology, CAD-assisted Chest X-Ray (CAD-CXR) has …
Junji Chen, Luqing Zhao, Xiang Zhou, Yi Mo, Lanting Kong, et al.
**BACKGROUND:** This study aimed to evaluate the safety and diagnostic performance of recombinant fusion protein early secretory antigenic target protein 6-culture filtrate protein 10 (EC) in a community-based population aged ≥6 months. **METHODS:** We conducted a 2-stage…
Bjorn Moum, M.D Ph.D, Gunnar Bjune, M.D Ph.D
…eases. By using non-invasive rapid tests one wishes to make diagnostics available to resource poor settings. Ideally, referrals to invasive diagnostic procedures would decrease, thus liberating economic and staff resources. Furthermore, patients may avoid unnecessary, expensive a…
Jayne S Sutherland, Gian D van der Spuy, Jane A Shaw, Tracy Richardson, Elisa M Tjon Kon Fat, et al.
**BACKGROUND:** Non-sputum-based, point-of-care triage tests for pulmonary tuberculosis could enhance tuberculosis diagnostic programs. We assessed the diagnostic accuracy of 2 finger-stick blood tests: the Cepheid 3 gene host-response cartridge (Xpert-HR), which measures 3 host …
Anton Vladzymyrskyy
Testing of AI solutions to assess diagnostic accuracy for tuberculosis detection. Tuberculosis remains a key problem of modern medicine. New approaches for burden overcoming should be proposed. New screening strategies may include artificial intelligence (AI). An AI-based system…
Mārcis Leja, PhD, MD, Lelde Lauka, MD, Andra Cīrule, MD
Detection of Volatile Organic Compounds (VOC) directly from tissue by headspace analysis (skin, surgery material, other tissue) and exhaled breath is feasible using affordable user-friendly novel nano-chemo sensors that can accurately be used for screening and monitoring purpose …
St George's, University of London
Improved diagnostics for paediatric Tuberculosis Research Question: To test the feasibility of TiKa system to reliably detect Mycobacterium tuberculosis in faeces of paediatric patients with Tuberculosis Study Design: Non-randomised diagnostic proof of concept feasibility study …
Molly F. Franke, ScD
The long term goal of this project is to provide information critical to the development and use of a low-cost, point-of-care, rapid, simple, and highly accurate diagnostic tool that can help clinicians make a microbiological diagnosis in children who present with signs and sympt…
Assiut University
* Detection of sensitivity and specificity of microscopic examination and Molecular studies using polymerase chain reaction (PCR) Mycobacterium tuberculosis (MTB)/ non tuberculous mycobacterium (NTM) MDR-TB compared to culture which is the gold standard technique in the diagnosis…
Jeong Ha Mok, Master, Jung Seop Eom, Master
The purpose of this study is to compare the diagnostic efficacy of nested and realtime polymerase chain reaction for Mycobacterium tuberculosis using EBUS-TBNA samples in patients with isolated intrathoracic lymphadenopathy. Although endobronchial ultrasound-guided transbronchia…
Scott K Heysell, MD
Major Research Aim: To study novel molecular diagnostics and the pharmacokinetic variability among a spectrum of TB disease states, including severe forms of TB like disseminated TB, TB meningitis and drug resistant TB, among adults and children from multiple international sites.…
Chin-Chung Shu, MD
1. To investigate the difference of PE inflammation/apoptosis-associated markers between TB pleurisy and non-TB pleurisy 2. To investigate the difference of neutrophil apoptosis in exudative PE between TB pleurisy and non-TB pleurisy 3. To investigate the change of apoptosis patt…
Joan Cayla, MD, Henrik Aggerbeck, M. Sc.
…C-Tb test. The TESEC-06 trial is an open comparison of the diagnostics performance of C-Tb compared to QuantiFERON®-TB Gold In-Tube, in combination with a double-blind randomized split-body safety assessment of C-Tb versus Tuberculin PPD RT23 SSI. The trial is designed to addre…
Theodora Mbunda, MD, PhD, Denise F Banze, MD, Junior Mutsvangwa, MD
The ERASE - TB study will be conducted in order to fill a critical unmet need for tuberculosis control. Persons who are in contact with an infectious TB case may become infected themselves. Among those who are infected, most will stay healthy but some will develop TB themselves. …