Showing 26–49 of 49 documents
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Valeria C Rolla, PhD, Valeria C Rolla, PhD
…d safety. This study may benefit patients co-infected with TB/HIV, particularly those with advanced immunodeficiency and who have shown failure to antiretroviral regimens including efavirenz or who may have any contraindication to their use (hypersensitivity or intolerance). Th…
Centre for Infectious Disease Research in Zambia
…throughout the developing world. Zambia is among the top 30 TB/HIV high burden countries. Chest X-ray (CXR) is recommended as a triaging test for TB, and a diagnostic aid when available. However, many high-burden settings lack access to experienced radiologists capable of interpr…
Surendra K Sharma, MD, Ph.D
…ted with TB. There are an estimated 12 million persons with TB/HIV co-infection. According to UNAIDS estimates, 5 million people have acquired HIV/AIDS in 2003. India is estimated to have 5.1 million HIV individuals by the end of 2002. TB is among the most frequent HIV-related op…
Klaus Reither
…lar, indigent people in hard-to-reach communities with high TB/HIV burden are at high risk of missed or delayed diagnoses. Hence, active case finding for TB remains an integral part of tuberculosis control in high-risk groups, such as people living with HIV (PLHIV) or diabetes me…
Aita Signorell, Alastair van Heerden, Irene Ayakaka, Bart Karl Jacobs, Marina Antillon, et al.
…rly concerning in hard-to-reach areas with a high burden of TB/HIV co-infection, where missed or delayed diagnoses exacerbate disease transmission, increase mortality and lead to severe economic and health consequences. To address these challenges, it is crucial to evaluate innov…
Liverpool School of Tropical Medicine
…igate the effectiveness and cost-effectiveness of optimised TB/HIV diagnosis and treatment linkage interventions on TB and HIV case detection, treatment initiation and mortality. Study design A pragmatic open, three-arm individually-randomised controlled trial and economic evalu…
University of Oxford
…wed that lower Cmax of anti-TB drugs frequently occurred in TB/HIV coinfected patients and low Cmax of pyrazinamide was related to poor treatment outcomes. On the other hand Requena-Méndez A. et al's study showed the variation of rifampin Cmax was not related to HIV. Large betwee…
Institut National de la Santé Et de la Recherche Médicale, France
…t dosages did not reach target levels. In children that are TB/HIV co-infected, drug-drug interactions between anti-TB drugs and antiretroviral drugs are of concern. The investigators hypothesize that HIV-infection and SAM, each one on its own, may have an impact on TB drugs con…
Marc Lipman, MD
…ence of LTBI (with positive TST or IGRA) will be invited to TB/HIV clinic and quality of life scores recorded as part of the study. Research Questions: 1. To determine the feasibility, yield and cost--effectiveness of testing for M. tuberculosis infection in UK HIV infected ind…
Susan Dorman, MD, Payam Nahid, MD, MPH, Susan Swindells, MBBS, Richard Chaisson, MD, Ekaterina V Kurbatova, MD, PhD, MPH
…favirenz-based antiretroviral treatment among patients with TB/HIV co-infection taking efavirenz-based combination antiretroviral therapy and TB treatment with rifapentine Endpoints: Primary Endpoints: * Efficacy: TB disease-free survival at twelve months after study treatment…
Anchalee Avihingsanon, MD
… syndrome). Although, Efavirenz based HAART is preferred in TB/HIV with rifampicin containing antituberculosis. However, Efavirenz could not be used in case of NNRTI failure, intolerance or toxicity. It remains unknown how to optimally treat HIV /TB in populations in which rifamp…
Karen Jacobson, MD MPH
…acing-identifies only 8-19% of transmissions in high TB and TB/HIV burden settings. Thus there is a clear need to identify new groups and settings where TB transmission occurs. Spatial clustering of individuals with higher rates of progression from infection to disease, such as t…
Dathan Byonanebye Mirembe, MBChB, M.MED
…ntervention and control arms. 7. To compare knowledge about TB/HIV in patients enrolled in the intervention and control arms. 8. To determine the effect of CFLU-TB on adherence to clinic appointments. 9. To determine the level of usage of the CFLU-TB tool in patients and their ca…
Robert S Wallis, MD, FIDSA, Hardy Kornfeld, MD
…ulosis treatment (ATT) and anti-retroviral therapy (ART) in TB/HIV co-infected patients. HIV-positive adults (treated or ART-naïve) newly diagnosed with sputum culture-positive, drug-sensitive pulmonary TB will be recruited to and enrolled in the study. All participants in the in…
Awewura Kwara, MD, MPH&TM
…rs. A two-arm parallel assignment pharmacokinetic study in TB/HIV co-infected children will be performed at the KATH. Children aged 3 - 35 months with HIV infection with or without TB coinfection, antiretroviral therapy (ART)-naïve, not previously exposed to nevirapine will be e…
Barcelona Institute for Global Health
…d work will be conducted. The district of Manhiça is a high TB/HIV burden area in Southern Mozambique, where the latest reported TB case notification is around 500 per 100,000 population and the prevalence of HIV in the adult population was 35%. TB QUEST will conduct an initial …
Salim S Abdool karim, MBChB, PhD
…r-positive pulmonary TB patients will be enrolled. Eligible TB/HIV co-infected patients will be offered antiretroviral therapy (ART), starting at one of the three time points listed above through the CAPRISA AIDS treatment programme which includes extensive counselling and adhere…
Grant Theron, PhD, Balthazar Nyombi, PhD, Kidist Bobosha, PhD, Carol Holm-Hansen, PhD
…n, SeroSelectTB is sensitive among adults co- infected with TB/HIV. Primary objective of field trial is to evaluate the diagnostic delay, measured as the time from TB diagnostic to TB treatment initiation between two groups of patients: those who were screened with SeroSelectTB …
Awewura Kwara, MD
Tenofovir (TFV) disoproxil fumarate (TDF) plus emtricitabine (FTC) or lamivudine (3TC) is the preferred nucleoside backbone of first-line antiretroviral therapy (ART) for adolescents in sub-Saharan Africa. In addition, TDF/FTC is recommended for preexposure prophylaxis (PrEP) for…
Centre Hospitalier Universitaire Saint Pierre
Objective Prospectively describe the kinetics of 18F-FDG uptake of extrapulmonary TB after two months and at the end of TB treatment in HIV patients. Evaluate 18F-FDG-PET/CT as a TB treatment response monitoring tool. Design The investigators performed baseline FDG-PET/CT, anoth…
Marcia Weaver, PhD, Sarah Naikoba, BMBCh, MPH
This evaluation aim is to investigate a cost-effective way to build capacity for the care and prevention of infectious diseases among mid-level practitioners (MLP) in sub-Saharan Africa. Classroom based training continues to be the dominant form of training, despite evidence that…
Neha Sharma, PhD
The purpose of the study is to evaluate the effect of homeopathy as an adjuvant to Anti tuberculosis treatment on sputum conversion, hematological, clinical sign and symptoms of relapsed Pulmonary TB.
Bahirdar University
The study might come up with valuable findings to address poor treatment outcome, poor quality of life, disability score and depressive symptoms. The findings may also be decreased health professional workload. The findings would be supportive evidences for policy makers, program…
Monde Muyoyeta, MD, PhD
Tuberculosis and HIV continue to be major public health problems in resource constrained settings like Zambia. Zambia is among the top 30 highest burden countries globally. The major drivers of TB in the Africa region is the HIV epidemic. Inadequate TB diagnostic tools with failu…