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Betina Durovni, Marcelo Cordeiro-Santos, Solange Cesar Cavalcante, Renata Spener-Gomes, Jamile Garcia, et al.
**BACKGROUND:** Short-course tuberculosis preventive therapy with isoniazid and rifapentine (HP) is widely recommended, but the acceptability and safety of one month of daily HP (1HP) compared to three months of weekly HP (3HP) is uncertain. We compared treatment with these two r…
Haoxin Xu, Jingyu Zhou, Qingluan Yang, Yixuan Yang, Feiran Zhou, et al.
… the higher specificity and reliability of detecting latent tuberculosis (TB) infection, Mycobacterium tuberculosis-specific interferon (IFN)-γ release assays do not perform satisfactorily in predicting the risk of active TB (ATB) development. It is crucial to identify new …
Weijian Liu, Nuo Xu, Wei Li, Wen Yao Mak, Tian He, et al.
…ety of 4-week daily rifapentine-isoniazid regimen in latent tuberculosis for Chinese children, and to provide paediatric-specific evidence for extrapolating adult dosing strategies to children. **METHODS:** An open-label, prospective, single-arm clinical trial was conducted amon…
Manjula Singh, Sindhu Joshi, Vikram Vohra, Rohit Sarin, Suchit Vasant Kamble, et al.
…ac in reducing the incidence of microbiologically confirmed tuberculosis (TB; pulmonary TB and extrapulmonary TB), development of latent TB infection, and immunogenicity. **DESIGN:** Phase 3 randomised clinical trial (PreVenTB trial). **SETTING:** 18 sites across six states of …