Showing 1–11 of 11 documents
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Noha Abdelgawad, Sean Wasserman, Kamunkhwala Gausi, Angharad Davis, Cari Stek, et al.
…trations above the critical concentration for Mycobacterium tuberculosis. **CONCLUSIONS:** CSF penetration with standard-dose rifampicin is low. Our findings support continued evaluation of high-dose rifampicin for TBM treatment.
Mailing Huang, Yujin Wang, Tao Chen, Yu Lu, Naihui Chu, et al.
Tuberculous meningitis (TBM) is the most severe form of tuberculosis (TB) with high mortality. This study evaluated the cerebrospinal fluid (CSF) concentration and safety of the novel oxazolidinone contezolid compared to linezolid in TBM patients. In this randomized prospective s…
Weicong Ren, Mengjie Yang, You Zhou, Yinghui Yang, Haoran Li, et al.
…rculous pleurisy (TP), a predominant form of extrapulmonary tuberculosis, presents significant diagnostic challenges attributable to the paucibacillary nature of pleural effusion (PE) specimens. Cell-free Mycobacterium tuberculosis (MTB) DNA in PE represents a promising biomarker…
Jose M Calderin, Sean Wasserman, Juan Eduardo Resendiz-Galvan, Noha Abdelgawad, Angharad Davis, et al.
…ere consistent with previously reported values in pulmonary tuberculosis, even when co-administered with high-dose rifampicin.
Dvijen Purohit, Rob van Wijk, Paddy Kafeero, Freddie Kibengo, Matthew Zimmerman, et al.
…berculous meningitis (TBM), a severe form of extrapulmonary tuberculosis, requires sustained therapeutic drug concentrations in the central nervous system (CNS). Linezolid is a promising treatment for TBM due to excellent CNS penetration and bactericidal activity against. However…
Jose M Calderin, Juan Eduardo Resendiz-Galvan, Noha Abdelgawad, Angharad Davis, Cari Stek, et al.
**BACKGROUND:** Dexamethasone is recommended as adjunctive therapy for tuberculous meningitis (TBM). Co-administration with rifampicin is expected to reduce dexamethasone exposure in TBM, an effect that may be more pronounced with the higher rifampicin doses currently being evalu…
Julie Huynh, Chishala Chabala, Suvasini Sharma, Louise Choo, Varinder Singh, et al.
…conditional recommendation that 6 months of intensified antituberculosis therapy (ATT) could be used as an alternative for drug-susceptible TBM. However, this has never been evaluated in a randomised clinical trial. Trials evaluating ATT shortening regimens using high-dose rifamp…
Meena Chandu, Rohit Bhatia, Manish Modi, Ritu Shree, Imnameren Longkumer, et al.
**BACKGROUND:** Cerebral infarction is a frequent and serious complication of tuberculous meningitis (TBM), contributing substantially to morbidity and mortality. Moreover, studies on infarct patterns and associated factors/predictors remain limited in TBM. ACT-TBM trial (Aspirin…
Joseph Donovan, Nguyen Duc Bang, Huu Khanh Trinh Dong, Dang Trung Nghia Ho, Thi Anh Thu Nguyen, et al.
Adjunctive corticosteroids such as dexamethasone are recommended in tuberculous meningitis treatment, despite modest and heterogeneous survival benefit. Leukotriene A4 hydrolase (LTA4H) genotypes associate with distinct intracerebral inflammatory phenotypes and may determine cort…
David B Meya, Fiona V Cresswell, Biyue Dai, Nicole Engen, Kogieleum Naidoo, et al.
**BACKGROUND:** Tuberculous meningitis is often lethal, and many survivors have disabilities despite antimicrobial treatment and adjunctive glucocorticoid therapy. Standard-dose rifampin has limited central nervous system penetration. Whether high-dose rifampin could improve surv…
Felicia C Chow, Paddy Kafeero, Maria Nakimbugwe, Anthony Ssemaganda, Colman Tayebwa, et al.
**BACKGROUND:** Tuberculous meningitis (TBM)-related deaths occur early, often within weeks after treatment initiation. Enhanced treatment early in the disease course with agents that effectively penetrate the central nervous system may improve outcomes in TBM. **METHODS:** We c…