Showing 1–20 of 20 documents
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Thibaut Gelé, Daniel Atwine, Elisabeth Baudin, Winnie Muyindike, Kenneth Mworozi, et al.
…atment duration. Although previous data among patients with HIV-TB coinfection has shown that doubling rifampicin dosing had a small effect on EFV concentrations, its effect on the pharmacokinetics (PK) of antituberculosis drugs remains lacking in this population. **OBJECTIVES:*…
Allan Kengo, Juan Eduardo Resendiz-Galvan, Letisha Najjemba, Henry Mugerwa, Amedeo De Nicolò, et al.
…ment of tuberculosis (TB) and human immunodeficiency virus (HIV) is complicated by drug-drug interactions (DDI). This analysis aimed to characterize the DDI between ritonavir-boosted atazanavir (ATV/r) and rifampicin in plasma and peripheral blood mononuclear cells (PBMC). **MET…
Kate Shearer, Bareng A S Nonyane, Christiaan Mulder, Emmanuel Kaonga, Rose Nyirenda, et al.
…ntive treatment (TPT) is underused among people living with HIV (PWH). We evaluated the effectiveness of a behavioural economics-based choice architecture approach to increase facility-level TPT prescribing to PWH in Malawi, Mozambique and Zimbabwe. **METHODS:** We conducted a c…
J Shenje, G Maartens, L Moran, Y Cramer, J D L Rios, et al.
… treatment of multidrug-resistant TB. It is unclear whether HIV affects the pharmacokinetics of bedaquiline and delamanid.</sec><sec><title>METHODS</title>Participants with multidrug-resistant TB were randomised to treatment with bedaquiline, delamanid, or both, plus a standard-o…
Lebohang M Mlambo, Minja Milovanovic, Colleen F Hanrahan, Kegaugetswe Motsomi, Mashido T Morolo, et al.
… and social support for accountability. The introduction of HIV testing during HCI was reported by some participants as making household members slightly uncomfortable, decreasing interest in household members being tested for TB. HCI negatively impacted community-level TB and HI…
Lebohang M Mlambo, Matshepo Setlaleleng, Kate Shearer, Nombuyiselo J Mofokeng, Phineas Ndou, et al.
…lobal health challenge, particularly for people living with HIV/AIDS (PLWHA). TB preventive treatment (TPT) has been found to reduce the risk of TB among PLWHA. As TPT has become a standard component of HIV care, understanding client-level perceptions and knowledge of TPT is cruc…
Phuti Choshi, Sarah Pedretti, Tafadzwa Chimbetete, Rama Gangula, Muki Shey, et al.
…od. Here, we conducted a study including well characterised HIV-TB coinfected patients with (n = 86) and without (n = 124) TB-IRIS from the randomized, double-blind, prophylactic prednisone trial (PredART study) with HLA, ERAP and KIR genotyping data. …
Michelle A Kendall, Michael D Hughes, Soyeon Kim, Lisa A Aaron, Linda Naini, et al.
…defined as young children <5 years, people living with HIV or non-HIV immunosuppression, or people with evidence of M. tb infection. The study was originally designed to enroll 3452 HHCs to provide 90 % power to detect a 50 % reduction in the cumulative proportion …
Shriya Misra, Thandanani Madonsela, Katherine K Thomas, Cole Grabow, Meena Lenn, et al.
…tious disease deaths, particularly among people living with HIV (PWH). Despite being preventable, TB preventive therapy (TPT) uptake is low in high-burden regions like South Africa, where new guidelines have expanded TPT eligibility and introduced shorter, more effective regimens…
R Perumal, S Pillay, N Bagratee, J Tulsi, N Naidu, et al.
…at least two prior episodes of TB, and 70% were living with HIV. Pulmonary function testing identified 25% (5/20) of individuals with restriction, 15% (3/20) with obstruction, and 20% (4/20) with mixed physiology. Air-trapping was present in 35% (7/20). CT revealed that fibrosis,…
Laura Diab Casares, Juan Espinosa Pereiro, María Teresa Tórtola Fernández, Xavier Casas García, Joan Pau Millet, et al.
… criteria include corrected QT interval (QTc) prolongation, HIV positive status, severely impaired blood counts or the use of QTc-prolonging drugs. The study will enrol 120 patients (60 per arm) over a 2.5-year period across 13 TB units in Spain. **ETHICS AND DISSEMINATION:** Th…
Tomas O Jensen, Shweta Sharma, Anchalee Avihingsanon, Joseph Lutaakome, Indira Brar, et al.
…t below cells/mmor other clinical indication in people with HIV (PWH) carries an increased risk of severe bacterial infections and tuberculosis (TB). It is not known if this increased risk is reversed after ART initiation. **METHODS:** We analyzed 4684 adult PWH with CD4 cell co…
Grace Montepiedra, Lisa Aaron, Gerhard Theron, Katie McCarthy, Sarah Bradford, et al.
…ferring to week 12 postpartum (deferred IPT) in people with HIV on antiretroviral therapy, showed higher than expected hepatotoxicity. We investigated the potential roles of antiretrovirals, isoniazid, pharmacogenetics and other factors. **METHODS:** Hepatotoxicity was defined a…
Menonli Adjobimey, Anete Trajman, Mayara Lisboa Bastos, Chantal Valiquette, Diana Gibson, et al.
…TBD are preferred but can be skipped in persons living with HIV and children <5 years. There is equipoise on the need for these tests in other HHC. **METHODS:** We conducted a superiority, open label cluster-randomized trial in Benin and Brazil to compare three strategies to eva…
Sara Domínguez-Rodríguez, David Lora, Alfredo Tagarro, Cinta Moraleda, Álvaro Ballesteros, et al.
…s and 15-day and 1-year mortality among infants living with HIV hospitalized with severe pneumonia in Africa. **METHODS AND DESIGN:** The EMPIRICAL trial (NCT03915366) is an international multicenter phase II-III, open-label randomized factorial clinical trial conducted in six A…
Rachael M Burke, Saulos K Nyirenda, Timeo Mtenga, Hussein H Twabi, Elizabeth Joekes, et al.
**BACKGROUND:** People with human immunodeficiency virus (PHIV) admitted to the hospital have high mortality, with tuberculosis (TB) being the major cause of death. Systematic use of new TB diagnostics could improve TB diagnosis and might improve outcomes. **METHODS:** We conduc…
Seda Yerlikaya, Masuzyo Chirwa, Bukola Ajide, Maria Del Mar Castro, Huy Ha, et al.
**BACKGROUND:** Improved diagnostic tools for tuberculosis that are suitable for use in peripheral health centers are essential for reducing the persistent gap between estimated and notified cases. The diagnostic accuracy and usability of the MiniDock MTB test for detecting pulmo…
Álvaro H Borges, Marisa Russell, Dereck Tait, Thomas J Scriba, Elisa Nemes, et al.
…l site), we enrolled participants aged 18-60 years, without HIV, who had completed more than 5 months (22 weeks) of treatment for drug-susceptible pulmonary tuberculosis. During trial screening (≤7 days after starting treatment), two sputum samples were obtained and frozen…
Alexander C Schmidt, Lee Fairlie, Elizabeth Hellström, Angelique Luabeya Kany Kany, Keren Middelkoop, et al.
… point) in QFT test-negative, human immunodeficiency virus (HIV)-negative adolescents. Adverse events were assessed in a secondary analysis, and immunogenicity was assessed in an exploratory analysis. Vaccine efficacy was evaluated in the modified intention-to-treat population, w…
Aita Signorell, Alastair van Heerden, Irene Ayakaka, Bart Karl Jacobs, Marina Antillon, et al.
… concerning in hard-to-reach areas with a high burden of TB/HIV co-infection, where missed or delayed diagnoses exacerbate disease transmission, increase mortality and lead to severe economic and health consequences. To address these challenges, it is crucial to evaluate innovati…