Showing 1–10 of 10 documents
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Marc Lipman, Ibrahim Abubakar, Colin Nj Campbell, Caroline Clarke, Andrew J Copas, et al.
…UND AND OBJECTIVES:** Tuberculosis remains a United Kingdom health concern. It occurs predominantly in people who have lived in tuberculosis endemic countries or have links there. Adherence to anti-tuberculosis treatment can be challenging, especially for people who experience se…
Mgcini Moyo, Thobani Ntshiqa, Yohhei Hamada, Andrew Copas, Issa Sabi, et al.
…ks of diagnosis at the time of recruitment by study team at health facilities in selected districts or regions. Each TB index patient and their contact(s) will be randomised into either universal TB testing or standard TB screening arms. Household and community contacts listed by…
Julie Huynh, Chishala Chabala, Suvasini Sharma, Louise Choo, Varinder Singh, et al.
…c biomarkers, in-depth neurodevelopmental outcomes, MRI and health economics. **ETHICS AND DISSEMINATION:** Local ethics committees at all participating study sites and respective regulators approved the SURE protocol. Ethics approval was also obtained from UCL, UK (14935/001). …
Prakash Ghosh, Shaheda Anwar, Martin Siegel, Julius Boniface Okuni, Manfred Weidmann, et al.
… with cervical lymphadenitis will be enrolled from tertiary healthcare facilities in Bangladesh and Uganda. Each participant will be subjected to laboratory investigations including microscopy, real-time PCR, cytology, culture and Xpert MTB/RIF Ultra with the tissue sample follow…
Aita Signorell, Alastair van Heerden, Irene Ayakaka, Bart Karl Jacobs, Marina Antillon, et al.
…RODUCTION:** Tuberculosis (TB) remains a significant public health challenge in many African communities, where underreporting and underdiagnosis are prevalent due to barriers in accessing care and inadequate diagnostic tools. This is particularly concerning in hard-to-reach area…
Nida Khan, Muhammad Ahmar Khan, Naila Muzaffar, Ahmad Ismail, Abdul Ghafoor, et al.
…iotics with reduced treatment duration are available. World Health Organization guidelines recommend the use of shorter all-oral regimens under operational research. To guide recommendations, we will compare two all-oral, short (≤ 11 months) regimens for the outcome…
Joanna Orne-Gliemann, Clémentine Roucher, Celso Khosa, Graeme Hoddinott, Marc d'Elbée, et al.
…d unreported to national TB programmes (NTPs) and the World Health Organization (WHO). This is mainly due to poor performance of microbiological tests, limited clinical skills and structural barriers for childhood TB diagnosis at decentralised levels of care. Treatment decision a…
Emilyn Costa Conceição, Karla Valéria Batista Lima, Cristiane Cunha Frota, Theolis Costa Barbosa Bessa, Adriana Ayden Ferreira, et al.
…le-genome sequencing (WGS), which are pivotal for precision health approaches and drug-resistant TB (DR-TB) surveillance. This study aims to strengthen genomic TB surveillance in the North and Northeast Brazilian regions by applying WGS to study DR-TB cases, training professional…
Saima Bashir, Lelisa Fekadu Assebe, Akash Malhotra, Délio Elísio, Antonio Machiana, et al.
…stimated incremental participant costs for TB diagnosis and health outcomes (number of participants who initiated treatment within seven and sixty days) across SES groups. Distributional cost-effectiveness analysis assessed facility-based diagnostic cost per treatment initiated f…
Kate Shearer, Bareng A S Nonyane, Christiaan Mulder, Emmanuel Kaonga, Rose Nyirenda, et al.
… HIV (PWH). We evaluated the effectiveness of a behavioural economics-based choice architecture approach to increase facility-level TPT prescribing to PWH in Malawi, Mozambique and Zimbabwe. **METHODS:** We conducted a cluster-randomised trial within the IMPAACT4TB 3HP rollout, …