TB Research

A Case of Immunoglobulin A Vasculitis Induced by Ethambutol.

Kazuhiko Nakagawa, Takuma Ikeda, Yuki Yoshida, Shohei Yano, Shota Takahashi, Takafumi Yamano, Tatsuya Ogimoto, Moon Hee Hwang

Internal medicine (Tokyo, Japan) · 2026-04

Abstract

Immunoglobulin A vasculitis (IgAV) is a systemic vasculitis characterized by IgA deposition within the vessel walls. In recent years, an increasing number of IgAV cases associated with tuberculosis infection have been reported. We present the case of a 72-year-old man who developed IgAV after the initiation of treatment for pulmonary tuberculosis, with ethambutol considered to be the causative agent based on the clinical course. In most cases, it is difficult to identify the exact etiology of IgAV, and no standardized management strategy has yet been established. Nevertheless, when drug-induced IgAV cannot be excluded, discontinuation of the suspected drug should be prioritized.