B45-27 Association of Six-Minute Walk Test Distance and Percentage of Viable Lung on Perfusion Scan With the Development of Postoperative Pulmonary Complications After Lung Resection in Patients With Bronchiectasis and/or Aspergilloma

Abstract Rationale Lung resection is a high-risk surgery. Thus, preoperative evaluation and prognostication are important to establish that the patient can withstand the planned procedure and will have sufficient pulmonary reserve. Pulmonary function test (PFT) has a crucial part that predicts the impact of surgery on a patient with compromised respiratory function. However, active hemoptysis—a contraindication for performing PFT—frequently occurs in patients undergoing resection for bronchiectasis and/or aspergilloma. Hence, alternative strategies for preoperative pulmonary assessment are imperative, especially in a resource-limited setting. This study determined the association of six-minute walk test (6MWT) distance and percentage of viable lung measured by lung perfusion scan (LPS) in predicting postoperative pulmonary complications (PPC) among Filipino patients with bronchiectasis and/or aspergilloma who underwent lung resection. Method This is a retrospective cohort study among Filipino patients with hemoptysis due to bronchiectasis and/or aspergilloma who underwent lung resection in a tertiary hospital. Purposive sampling design was utilized. Descriptive statistics, Fisher’s exact/chi-square test, crude and adjusted odds ratio (OR), and multivariable binary logistic regression analysis were utilized. Results Among 84 patients, majority were <50 years old (58%), males (64%), normal BMI (71%), non-smoker (58%), with diabetes mellitus (17%), underwent lobectomy (74%), 8-14 days (46%) hospital stay, and diagnosed with bronchiectasis (48%). Six-minute walk test (6MWT) distance of ≤ 325 meters was significantly associated with outcomes. For every one-meter increase in 6MWT distance, the odds of developing postoperative pulmonary complications (PPC) or death decreased by 1.3% (p = 0.001). Patients aged ≥ 50 years had nearly fourfold higher odds of PPC or death compared with those < 50 years (OR = 3.8, p = 0.005). Likewise, patients with a 6MWT distance ≤ 325 meters had a sevenfold higher risk of complications or death (OR = 7.1, p = 0.004). In the multivariable binary logistic regression analysis, only 6MWT distance remained significantly associated with the occurrence of at least one PPC or death. In contrast, the percentage of viable lung on lung perfusion scan (LPS) showed no significant association with PPC (p = 0.517; statistical power = 0.77). However, the sample size is small for further analysis. Conclusion Six-minute walk-test (≤ 325 meters) was associated with development of at least one post operative pulmonary complication or death among patients with hemoptysis due to bronchiectasis and/or aspergilloma who underwent lung resection. This abstract is funded by: None