B69-05 Procalcitonin Levels as a Prognostic Indicator for Mortality in Hospitalized Pulmonary Tuberculosis Patients: A Study From Indonesia’s National Referral Center for Respiratory Diseases

Abstract Rationale Procalcitonin (PCT) is a biomarker used to indicate infection and inflammation severity. Its role in pulmonary tuberculosis (TB) remains unclear, with studies showing mixed results regarding its diagnostic and prognostic value. This study aims to evaluate the association between PCT levels and mortality among hospitalized patients with pulmonary TB. Methods We conducted a single-centre retrospective cohort study as part of the HI-PROPHET Study, utilizing data extracted from the National TB Information System (SITB) and the electronic medical records of Persahabatan Hospital, a national referral center for respiratory diseases in Indonesia. Individuals aged ≥18 years with confirmed pulmonary TB who were hospitalized at Persahabatan Hospital between 2020 and 2024 were included and classified by PCT levels as < 0.5 µg/L or ≥ 0.5 µg/L. Each eligible individual was followed for 28 days from the date of hospitalization. Data were analyzed using SPSS version 24. Univariate and multivariate logistic regression analyses were performed to assess the association between PCT levels and mortality as a prognostic indicator in TB patients, while controlling for potential confounders. Results Among 103 individuals with pulmonary TB, 62 had PCT levels <0.5 µg/L, with 3 identified as non-survivors. PCT levels ≥0.5 µg/L were observed in 41 individuals, among whom 11 were non-survivors (aOR 6.46, 95% CI 1.59-26.18, P = 0.009). Age and smoking status were included in the model but were not significant independent predictors (age [aOR 0.970, 95% CI 0.92-1.01, P = 0.970], smoking [aOR 0.396, 95% CI 0.096-1.63, P = 0.396]). The predictive performance of PCT alone, assessed by the area under the receiver operating characteristic (ROC) curve, was 0.724 and increased to 0.807 when combined with age and smoking status. Conclusion These findings highlight that PCT levels ≥0.5 µg/L are an independent factor associated with mortality in hospitalized TB patients, particularly when evaluated alongside age and smoking status. This abstract is funded by: None