Inhibitory effects of thiophene-2-thiazole hybrids against sensitive strains and resistant clinical isolates of Mycobacterium tuberculosis
Paulo Fernando da Silva Santos-Júnior, Valnês S. Rodrigues-Junior, Monalisa Silva, Edjan Carlos Dantas da Silva, Marcia Alberton Perelló, Alexia de Matos Czeczot, Cristiano Valim Bizarro, Pablo Machado, et al. (14 authors)
Bioorganic & Medicinal Chemistry Letters · 2026-05
Abstract
. Compound 3c retained bactericidal activity under nutrient-starvation conditions and outperformed isoniazid (INH) in a dormancy model. Cytotoxicity assays in HepG2 and Vero E6 cells showed low toxicity (IC₅₀ > 100 μM). These findings identify 3c as a promising lead scaffold for anti-TB drug development.
MeSH terms
- Cytotoxicity
- Vero cell
- Isoniazid
- Mycobacterium tuberculosis
- Chemistry
- Antimycobacterial
- Microbiology
- In vitro
- Minimum inhibitory concentration
- Toxicity
- Tuberculosis
- Drug resistance
- Inhibitory postsynaptic potential
- Bacteria
- Drug
- Antibacterial agent
- Biological activity
- Lead compound
- Cell culture
- Virology