Clinical profile and predictors of mortality among people living with HIV/AIDS with <i>Mycobacterium tuberculosis</i> detected in blood or bone marrow at a tertiary hospital in Northeast Brazil
Adriano Monteiro da Silva, Pedro Ítalo Oliveira Gomes, Ivna Felice Silva Matos, Ednaldo Pereira Lima Sobrinho, Luís Arthur Brasil Gadelha Farias, Lauro Vieira Perdigão Neto
Tropical Doctor · 2026-03
Abstract
Mycobacterium tuberculosis bacteraemia is a severe manifestation of tuberculosis in people living with human immunodeficiency virus acquired immune deficiency syndrome, associated with high mortality. We found patients with fatal outcomes had significantly lower lymphocyte, platelet, and CD4+ T-lymphocyte counts, and higher urea levels ( p < 0.05). CD4+ T-lymphocyte count <32 cells/mm 3 was independently associated with mortality ( p = 0.005). The oral rifampicin, isoniazid, pyrazinamide, and ethambutol regime was more frequent among survivors. Social vulnerability factors were common but not independently associated with mortality.
MeSH terms
- Medicine
- Ethambutol
- Tuberculosis
- Internal medicine
- Pediatrics
- Immune system
- Bone marrow
- Human immunodeficiency virus (HIV)
- Immune status
- AIDS-Related Opportunistic Infections
- Viral disease
- Young adult