STUDY OF THE PREVALENCE AND RISK FACTORS OF ANTI TUBERCULOSIS DRUG INDUCED HEPATOTOXICITY AMONG PULMONARY TUBERCULOSIS PATIENTS ATTENDED AL-MADAEN GENERAL HOSPITAL IN BAGHDAD-IRAQ

Background: The first-line anti-TB drugs are potentially hepatotoxic and many factors have been reported to increase the risk of developing hepatotoxicity in patients with anti-TB therapy. Objectives: To determine the prevalence of hepatotoxicity among patients on anti-TB drug and to find any associated factors. Methods: A cross- sectional study held on 178 TB patients those admitted to Al-Madaen General hospital during the period from October 2023 to April 2024. Data were collected using a structured questionnaire, composed of socio- demographic characteristics of the patients and medical history. Data were analyzed by using Statistical Package of Social Sciences Version 29. Results: More than half (61%) of the patients were new cases, 72% of patients had no TB family history, 57% of patients use HRZE regime, 99.4% of the patient were with history of concomitant hepatotoxic drugs, 9% had abnormal liver function test with significant associations with gender, occupation and type of TB case. Conclusion: The mechanism of hepatotoxicity in female TB patients is unclear. Low socio-economic status (non-employed), and poor health TB patient were more likely to develop hepatotoxicity.