An Rv1471-expressing chimpanzee adenovirus vaccine confers protection against tuberculosis by inducing alveolar macrophage trained immunity and polyfunctional T-cell responses
Hao Wang, Ying Zhang, Jianhui Li, Juan Wu, Shaoqiong Huang, Shiqi Xie, Xuejiao Huang, Jing Wang, et al. (10 authors)
Emerging Microbes & Infections · 2026-03
Abstract
challenge. Furthermore, rAd-Rv1471 acted as an effective heterologous booster, enhancing protection in BCG-primed mice. Our findings establish rAd-Rv1471 as a synergistic mucosal vaccine candidate that concurrently induces trained immunity in AMs and polyfunctional T-cell responses, highlighting a promising dual-targeting strategy for next-generation TB vaccines.
MeSH terms
- Innate immune system
- Immunology
- Immunity
- Heterologous
- Virology
- Nasal administration
- Immune system
- Tuberculosis
- Acquired immune system
- Tuberculosis vaccines
- Macrophage
- Biology
- Medicine
- Vaccination
- Mycobacterium tuberculosis
- Antigen
- Cellular immunity
- Alveolar macrophage
- Adenoviridae
- Virus