Prevalence and determinants of unsuccessful tuberculosis treatment outcomes among children in Northern Ghana: a retrospective review

Introduction Tuberculosis (TB) remains a leading cause of childhood morbidity and mortality, yet evidence on treatment outcomes and associated determinants in Northern Ghana remains limited. This study examined the prevalence, trends, and determinants of unsuccessful treatment outcomes among children with TB at Tamale Teaching Hospital from 2016 to 2024. Methods A retrospective review of secondary data was conducted among children ( Results Of 1,842 TB cases, 245 were children, of whom 233 had documented treatment outcomes and were included in the analysis. The median age was 5 years (IQR: 2-10), and 58.4% were males. Pulmonary TB accounted for 63.5% of cases, while 13.7% had TB/HIV coinfection. The treatment success rate was 75.5% (176/233), while 24.5% (57/233) experienced unsuccessful outcomes, including 11.2% deaths and 13.3% loss to follow-up, with no cases of treatment failure. In multivariable analysis, children aged Conclusion Nearly one in four children experienced unsuccessful TB treatment outcomes, mainly due to death and loss to follow-up. Younger age and rural residence were key predictors of poor treatment outcomes. Strengthening early diagnosis, decentralised care, and targeted adherence support for vulnerable groups is essential to improve outcomes.