Rifampin Exposure in Pregnant and Nonpregnant Women With Tuberculosis in India
Rao PS, Prakash Babu S, Ezhumalai K, Knudsen S, Ramakrishnan J, Joseph N, Cintron C, Dauphinais MR, et al. (17 authors)
The Journal of infectious diseases · 2026-03
Abstract
This prospective cohort study evaluated rifampin pharmacokinetics in pregnant and nonpregnant women with tuberculosis in India. Pregnant women had significantly lower drug exposure, with <20% of the participants achieving target concentrations at any trimester. Findings highlight potential underdosing in pregnancy and underscore the need for dedicated pharmacokinetics studies in pregnancy, and revised rifampin dosing guidelines.
MeSH terms
- Humans
- Tuberculosis
- Pregnancy Complications, Infectious
- Rifampin
- Antitubercular Agents
- Prospective Studies
- Pregnancy
- Adolescent
- Adult
- India
- Female
- Young Adult