Pyrimidine-Based Compounds in Tuberculosis Management: A Review of their Biological and Medicinal Importance

Pyrimidine derivatives are a class of chemically and biologically active heterocyclic compounds promising for developing anti-tubercular, anti-viral, anti-malarial, anti-inflammatory, and enzyme-inhibiting drugs. To cure TB, scientists were driven to establish novel pyrimidine derivatives. The main objective of the current review is to identify and develop new pyrimidine moiety- containing derivatives that have been assessed for their structure-activity relationship (SAR). Several drug-resistant MTB infections have emerged and spread worldwide, which has rendered first-line medication ineffective. It is crucial to develop new anti-TB drugs that are extremely effective against both drug-sensitive and drug-resistant TB. The development of pyrimidine therapeutic methods will thus benefit from the current review. Three medications-GSK-286, TBA-7371, and SPR-720 are now undergoing clinical testing. This study aims to emphasize the structural variety of anti-tuberculosis pyrimidine-containing compounds by providing an overview of current developments in drug discovery investigations.