The Prevalence of Polymorphism in Vitamin D Receptor Genes and its Correlation with Susceptibility to Pulmonary Tuberculosis in the Global Population (2010-2023): A Systematic Review and Meta-Analysis.

BACKGROUND: Single nucleotide polymorphisms (SNPs) in the vitamin D receptor (VDR) gene play a significant role in the susceptibility to pulmonary tuberculosis (TB). Recognition of these polymorphisms is a crucial aspect of TB treatment. This study aims to investigate the effects of VDR gene polymorphisms on TB susceptibility.

METHODS: This research encompassed studies from 2010 to 2023. The synthesis and integration of data, along with meta-analysis and qualitative heterogeneity investigation, were conducted using a documentation table. STATA 14 software was employed for meta-analysis, utilizing both the fixed and random effects models. To assess data heterogeneity, the Q test (< 0.10) with the chi-square &#x3c7;2 distribution at the 95% confidence level was employed. Two-sided statistical tests were conducted with= 0.05.

RESULTS: The highest pooled OR of genotype polymorphism of the VDR gene was associated with the FF (OR: 1.165, 95% CI; 0.953- 1.424), TT (OR: 1.163, 95% CI; 1.018- 1.329), Tt (95% CI: 0.768-1.095) and tt (95% CI: 0.594-1.416) each one OR: 0.917, Ff (OR: 0.888, 95% CI; 0.699- 1.130, weight: 100.00) and ff (OR: 0.648, 95% CI; 0.418- 1.006, weight: 100.00), respectively. The statistical difference between case and control groups was found to be significant in terms of TT genotype (= 0.026). A statistically significant difference was observed between individuals (Along with the polymorphism of VDR genes) with and without pulmonary TB.

CONCLUSIONS: The FF and TT genotypes exhibited the highest prevalence of polymorphism.