Regulation of mitochondria functions byinfection.

Tuberculosis, a leading killer among infectious diseases worldwide, is caused by().has strong ability to manipulate the intracellular environment of macrophages for successful surviving. Mitochondrion is a key organelle involved in diverse physiological processes, including Cafluxes, ATP synthesis, bioenergetic metabolism, and cell death, which are pivotal to cellular and organismal homeostasis. Mitochondrion is also targeted byto control various physiological responses of the host.has evolved a series of strategies to manipulate mitochondrial functions in favor of their survival, replication, and dissemination. In mitochondrion,regulates cell energy metabolism and cell death pathway. Herein, we reviewed the latest advances in the interactions betweenand mitochondria and discussed multiple aspects of the influence ofon mitochondrial metabolism to shed light on the-induced pathogenesis.