Adsorption of Isoniazid on Aluminum Silicate Tubular Structures.

Tubular morphologies were formed using chemical gardens from aluminum salts, aluminum silicate, where the external surface is formed mainly by silicate and the inner surface is mainly aluminum oxide-hydroxide. Several stages are observed during the formation of tubular aluminosilicates using the Schlieren technique. In this work, the adsorption of a bioactive organic compound on the tubular structures formed from aluminum nitrate and sodium silicate was explored, obtaining surprising results. These tubular structures exhibit a notable adsorption capacity for organic compounds and can transport pharmaceutical drugs, such as isoniazid, yielding up to 10% of the solid weight. They could also be used as an excipient in medicines. Molecular modeling studies of this adsorption process corroborated that it is energetically favorable. This material appears to be a promising candidate for the development of novel drug delivery systems for the treatment of tuberculosis.