A Silent Threat in Post-Tuberculosis Patients: Chronic Pulmonary Aspergillosis Survey in Multiple Regions of Indonesia (I-CHROME Study).

BACKGROUND: A significant complication among post-tuberculosis patients is chronic pulmonary aspergillosis (CPA), with prevalence and outcomes varying by region. This study aimed to explore the epidemiology, clinical characteristics, and microbiological profiles of 219 post-tuberculosis patients with persistent respiratory symptoms and lung cavities in Indonesia.

METHODS: The patients were divided into CPA (= 144) and non-CPA (= 75) groups. This cross-sectional study diagnosed CPA in post-tuberculosis patients using ERS/ESCMID criteria, integrating clinical, radiological, and fungal assessments. Serological tests for-specific IgG were conducted using immunochromatographic (ICT) and ELISA on serum samples. Sputum specimens were used in parallel for fungal culture, and radiological evaluations (e.g., chest X-rays or CT scans) were performed to identify typical CPA features such as cavitation and fibrosis.

RESULTS: Persistent cough was significantly more common in CPA patients (83.3%,= 0.015), highlighting its role as a clinical indicator for CPA. Radiological infiltrates were found in 165 patients (75.3%); critical diagnostic markers of CPA were cavitation and pericavitary fibrosis.-specific IgG testing demonstrated high diagnostic utility, with positivity rates of 69.4% for ICT and 63.2% for ELISA among CPA patients. Among those with infiltrates, a positiveculture was not more common (> 0.05), whereasIgG was more often raised (= 0.037), as was a positive ICT (= 0.021). Regional analysis revealed a higher CPA burden in Region 1 (75%) compared to Region 2 (56%,= 0.003), withandpredominating in Region 1.

CONCLUSIONS: These findings highlight the importance of comprehensive approaches and region-specific CPA management strategies in Indonesia.