Thec-54t compensatory mutation is not always a valid surrogate for isoniazid resistance in.
Viktória Szél, Jody E Phelan, Sophia B Georghiou, David L Dolinger, Taane G Clark, Stefan Niemann, Lilla K Lőrinczi, Claudio U Köser
Antimicrobial agents and chemotherapy · 2025-06
Abstract
Thirteen commercial genotypic antimicrobial susceptibility assays interrogate mutations upstream ofto infer isoniazid resistance for. We demonstrate that relying on one of these compensatory mutations (i.e.,c-54t)-rather than causative resistance mutations inthatcompensates for-can result in systematic false-resistant results for isoniazid with the Cepheid Xpert MTB/XDR and suboptimal treatment. The WHO mutation catalog should be refined to address this scenario.
MeSH terms
- Mycobacterium tuberculosis
- Isoniazid
- Antitubercular Agents
- Microbial Sensitivity Tests
- Mutation
- Bacterial Proteins
- Humans
- Drug Resistance, Bacterial
- Tuberculosis, Multidrug-Resistant
- Catalase