TB Research

Combating TB Pathology: Advanced Diagnostics, Innovative Therapies, and Public Health Strategies: A Review.

Satyajit Mohanty, Manmeet Kaur Khanna, Krishnendu Adhikary, Tuhin Mukherjee, Anwesha Sahu, Ivan Kahwa, Pranav Kumar Prabhakar, Mahendra Pratap Swain, et al. (10 authors)

Current pharmaceutical biotechnology · 2025-04

Abstract

Tuberculosis (TB) continues to be a major global health challenge, largely due to the complex nature of Mycobacterium tuberculosis. Its early detection and effective management are heavily reliant on advanced diagnostic methods. New drug delivery systems and repurposing existing drugs show great promise in improving TB treatment. This study explores the progress and hurdles in developing anti-TB drugs, focusing on those currently in clinical trials. Additionally, innovative approaches like immunotherapy, combination therapy, and adjunct therapy, which include the use of phytochemicals, are examined for their potential to enhance treatment outcomes and tackle drug resistance. These innovative approaches could be the key to the future of the fight against TB. It also highlights how these strategies could accelerate TB treatment. It incorporates public health strategies for preventing TB transmission and ensuring patients adhere to treatments. By addressing these key areas, this work aims to contribute to the global fight against TB and improve the lives of those affected by the disease.