Unraveling the role of IL-17A variants in pulmonary tuberculosis: Insights from a case-control study.

OBJECTIVES: The present study aimed to investigate the association between certain interleukin-17 A (IL-17 A) polymorphisms, specifically rs2275913 and rs8193036, and the susceptibility to pulmonary tuberculosis (PTB). Considering the function of IL-17 A in regulating immunological responses, especially regarding bacterial infections, we sought to determine if variations in the IL-17 A gene effect on PTB in the examined group.

METHODS: We performed a case-control study with 100 individuals who were confirmed to have PTB and 100 control subjects. Genotyping for the IL-17 A SNPs rs2275913 and rs8193036 was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and Tetra-primer Amplification Refractory Mutation System (Tetra-ARMS PCR) methodologies. A statistical analysis encompassing odds ratios (OR) and 95 % confidence intervals (CI) was conducted to assess the association between the polymorphisms and the risk of PTB.

RESULTS: Our data indicated a significant connection between the rs2275913 polymorphism and elevated susceptibility to PTB (OR&#x202f;=&#x202f;1.69, 95&#x202f;% CI: 1.09-2.61; p&#x202f;=&#x202f;0.031). Also, a significant association between the rs8193036 polymorphism and increased susceptibility to PTB (OR&#x202f;=&#x202f;2.18, 95&#x202f;% CI: 1.46-3.27; p&#x202f;<&#x202f;0.001).

CONCLUSION: The IL-17&#x202f;A polymorphisms rs2275913 and rs8193036 strongly correlate with increased susceptibility to PTB, according to this study. This suggests a potential genetic risk factor in the progression of the disease.