Chemical composition and antimycobacterial, anti-and cytotoxic activities of essential oils from(Sol. ex Gaertn.) G. Don leaves and flowers.
Irles J M M Silva, Cassia C Fernandes, Nagela B S Silva, Gabriel G Calefi, Carlos H G Martins, Jackson B A Silva, Antônio E M Crotti, Mayker L D Miranda
Natural product research · 2025-09
Abstract
has been widely known due to its therapeutic properties. Tuberculosis is a deadly infectious disease caused predominantly by. Other respiratory diseases may also be caused by nontuberculous mycobacteria.causes dermal inflammation and tissue damage. This study aimed to evaluateinhibitory effects of essential oils (EOs) fromleaves (EO-CL) and flowers (EO-CF) against,,andstrains. Their cytotoxic activity was evaluated by the brine shrimp assay. Resulting MIC values of all EOs under study were promising since they ranged from 50 to 100 µg/mL. Both EO-CL and EO-CF showed nontoxicity againstby the brine shrimp assay (LC> 1000 µg/mL). GC-FID and GC-MS analyses showed that 1,8-cineole was the major component of both EOs. These results revealed the promising potential of EO-CL and EO-CF to develop new antibacterial and antifungal drugs.
MeSH terms
- Oils, Volatile
- Plant Leaves
- Microbial Sensitivity Tests
- Flowers
- Artemia
- Anti-Bacterial Agents
- Animals
- Myrtaceae
- Malassezia
- Gas Chromatography-Mass Spectrometry
- Antifungal Agents
- Mycobacterium tuberculosis
- Eucalyptol