Mapping the Global Knowledge Evolution on Tuberculosis Treatment Adherence: A Bibliometric Analysis of Behavioral, Psychological, and Socioeconomic Determinants (2000–2024)

Abstract: - Background: Treatment adherence remains one of the most critical determinants of tuberculosis (TB) control, influencing treatment success, prevention of drug-resistant TB, and reduction of transmission. Understanding the global research landscape, thematic trends, and emerging priorities in TB treatment adherence requires a structured examination of existing scientific output. This study uses bibliometric analysis to map the intellectual structure, research evolution, and collaboration patterns in this field. Methods: Articles related to TB treatment adherence were retrieved from the Web of Science Core Collection using predefined search terms. Eligible records (2000–2024) were exported in plain text format. Statistical, network, and visualization analyses—including publication trends, citation performance, co-authorship, country and institutional collaboration, keyword co-occurrence, co-citation, thematic evolution, and citation burst detection—were conducted using Microsoft Excel and RStudio (bibliometrix package). Results: A total of 225 articles were included, averaging 42.18 citations per article and 305.65 citations per year. The United States led in publication output and international collaboration, followed by the United Kingdom, India, and South Africa. Keyword co-occurrence and burst analysis identified “digital adherence technologies,” “catastrophic costs,” “mental health and stigma,” and “treatment supporter engagement” as emerging research frontiers. Conclusion: Research on TB treatment adherence has shifted from traditional behavioral and DOTS-centered approaches toward integrated frameworks that incorporate digital health, psychosocial support, financial protection, and community engagement. Although developed countries dominate research output, contributions from high-burden regions are growing. Future research should prioritize innovation, context-specific solutions, and equity-focused strategies to strengthen global TB treatment adherence