Mycobacterium tuberculosis peptide-specific T cells in pulmonary granulomas display broad effector functions
Christine E Nelson, Keith D. Kauffman, Kevin C. Osum, Shunsuke Sakai, Jay Buchanan, Jean Michel Chanchu, Melanie Cohen, Julie Laux, et al. (22 authors)
iScience · 2025-11
Abstract
. In granulomas from a patient that underwent a pneumonectomy to remove tuberculosis-destroyed lung, we identify a population of peptide-specific T cells similar to macaque peptide-stimulated T cells. Thus, Mtb peptide-specific T cells may mediate protection against Mtb infection through the combined effects of many functions as well as the induction of bystander responses by neighboring T cells.
MeSH terms
- Bystander effect
- Biology
- Immunology
- T cell
- Mycobacterium tuberculosis
- Cytotoxic T cell
- Granzyme
- Granzyme B
- Interleukin 21
- Effector
- Immune system
- Population
- Tuberculosis
- Cell biology
- Granuloma
- Interleukin 12
- Virology
- Natural killer T cell
- Macaque