Clinical profile and outcome of AA amyloidosis associated kidney disease in India

BACKGROUND: AA amyloidosis is a rare but significant cause of chronic kidney disease (CKD). We aimed to characterize the clinical profile of patients with AA amyloidosis affecting the kidneys in the Indian subcontinent. METHODOLOGY: In this retrospective cohort study, we evaluated patients with kidney biopsy-confirmed AA amyloidosis and compared them with a control group of patients with diabetic kidney disease (DKD). Primary outcome was defined as a composite of ≥50% decline in estimated glomerular filtration rate (eGFR) and/or progression to end-stage kidney disease (ESKD). RESULTS: = 0.002). CONCLUSION: AA amyloidosis is an uncommon but important cause of CKD. Tuberculosis is the leading predisposing factor in Indian patients. These patients exhibit slower eGFR decline compared to DKD despite progressive proteinuria, suggesting distinct pathophysiology.