Recombinant <i>Mycobacterium smegmatis</i> expressing antigen 85B for immunotherapy of <i>Mycobacterium tuberculosis</i> -infected mice
Yuxiao Chang, Huanhuan Ning, Xuan Liang, Yanzhi Lu, Jian Kang, Xue Li, Shangqi Liu, L. Y. Hao, et al. (11 authors)
Human Vaccines & Immunotherapeutics · 2025-10
Abstract
T cells in spleen and lung, promoted Th1/Th2-type cytokines secretions, and increased inflammatory cytokines releases and alleviated pathological damages in the lung of Mtb infected mice. Moreover, rMs-Ag85B significantly reduced the Mtb loads in the spleen of mice. In conclusion, rMs-Ag85B vaccine provided an immunotherapeutic effect against Mtb infection and could be used as a candidate vaccine for the immunotherapy of tuberculosis.
MeSH terms
- Immunology
- Immune system
- Spleen
- Antigen
- Immunotherapy
- Medicine
- Adjuvant
- Recombinant DNA
- Immunization
- Vaccination
- Virology
- Tuberculosis vaccines
- Tuberculosis
- Cytokine
- Proinflammatory cytokine