TB Research

Future Perspectives and Emerging Strategies in Tuberculosis Drug Discovery

Mahesh T. Chhabria, Divya Teli

Apple Academic Press eBooks · 2025-10

Abstract

Tuberculosis (TB) remains a global health threat, with the emergence of drug-resistant strains posing significant challenges to traditional treatment approaches. This necessitates continuous innovation and the development of novel strategies in TB drug discovery. This chapter explores the latest advancements and potential breakthroughs in the field, providing comprehensive insights into targeting latent TB infection, host-directed therapies, personalized medicine, drug repurposing, targeting novel pathways for the development of novel chemical entities, and combination therapy. Overall, this chapter provides insights into the evolving landscape of TB drug discovery and underscores the importance of continued innovation and collaboration to address this persistent global health challenge.

MeSH terms

  • Tuberculosis
  • Drug discovery
  • Medicine
  • Drug development
  • Extensively drug-resistant tuberculosis
  • Drug
  • Engineering ethics
  • Global health
  • Data science
  • Precision medicine
  • Personalized medicine
  • Mycobacterium tuberculosis
  • Human health