Precision Prevention of Tuberculosis in Biologic Therapy: Lessons Beyond Screening Strategies

The 20-year experience of Prez-Recio et al. confirms that QuantiFERON-TB (QFT) alone is a safe and efficient baseline screening method before biologic therapy in low-incidence settings, with fewer diagnoses of latent tuberculosis (TB) and preventive treatments without excess active TB [1].However, several potential limitations and underexplored patterns reveal a more complex risk landscape that deserves closer consideration.