Oral Amyloidosis Secondary to Tuberculosis in an Adult Patient: A Report of a Rare Case

Oral amyloidosis involving the lateral border of the tongue secondary to tuberculosis is a rare clinical finding. We present the case of a 35-year-old woman with presumed amyloidosis secondary to tuberculosis after increased tongue volume and irregularly shaped lateral edges were noticed. The present study was motivated by the correlation between tuberculosis and its involvement as a trigger in the appearance of amyloidosis, which, in this case, presents with oral manifestations. This retrospective case report describes a patient whose incisional biopsy confirmed oral amyloidosis secondary to tuberculosis. The patient had a history of infectious diseases such as toxoplasmosis, histoplasmosis, cytomegalovirus, Epstein-Barr virus, and tuberculosis. The latter influenced the development of the amyloidosis process, suggesting an underlying immunological compromise that was not evaluated. The amyloidosis treatment begins with identifying the amyloid protein involved; since this is a serum amyloid A (SAA) protein, this finding is then related to the presence of an underlying chronic infectious inflammatory pathology.