Mixed infections and heteroresistance of <i>Mycobacterium tuberculosis</i> among multidrug-resistant tuberculosis in China: a genomic epidemiology study
Yan Liu, Yangyi Zhang, Xiaoyu Lu, Zheyuan Wu, Minjuan Li, Rui Zhang, Yixiao Lu, Renjie Hou, et al. (19 authors)
Emerging Microbes & Infections · 2025-08
Abstract
< 0.05). Isolates that were phenotypically susceptible but genotypically resistant harboured minority or low-frequency resistance mutations and were more common in patients with mixed infections and heteroresistance. In summary, mixed infections are significantly associated with heteroresistance, and both mixed infections and heteroresistance can lead to discrepancies between phenotypic and genotypic DST.
MeSH terms
- Tuberculosis
- Mycobacterium tuberculosis
- Epidemiology
- Multiple drug resistance
- Virology
- Molecular epidemiology
- Medicine
- Microbiology
- Biology
- Drug resistance