Clinical Characteristics of Tuberculosis Patients with Nephrological Pathology

The objective: tto study the structure of kidney disorders in tuberculosis patients. Subjects and Methods. Data from the unified medical information and analytical system (UMIAS) and medical records of 382 tuberculosis patients with nephrological pathology were retrospcetively analyzed. All those patients underwent in-patient treatment in Extrapulmonary Tuberculosis Department of Clinic no. 2, Moscow Research and Clinical Center for Tuberculosis Control of the Moscow Government Department of Health, from January 1, 2012 to December 31, 2022. Results. Acute kidney injury induced by anti-tuberculosis drugs was observed in 77/382 (20.2%) patients. Overall, drug-induced toxic nephropathy associated with tuberculosis treatment and comorbid conditions accounted for 111/382 cases (29.1%). Amyloidosis was detected in 42/382 (11.0%) patients, 23/382 (6.0%) underwent deceased-donor kidney transplantation. 61/382 (16.0%) patients had chronic glomerulonephritis. 95 patients received programmed hemodialysis. The main causes of end-stage renal disease in them were chronic glomerulonephritis (30–31.6%), amyloidosis (16–16.8%), and tubulointerstitial nephritis (12–12.6%). Emergency hemodialysis was performed in 43 patients, in 20 (46.5%) patients it was due to tubolointerstitial nephritis caused by anti-tuberculosis drugs, in 7 (16.3%) patients, it was due to some other drugs, and in 14 (32.6%) patients it was due to uric acid nephropathy.