TB Research

A dual-function probe for inhibition and rapid detection of <i>Mycobacterium tuberculosis</i>

Sonali Chhabra, Raman Parkesh

Chemical Communications · 2025-01

Abstract

by targeting the DprE1 enzyme, while also exhibiting antimicrobial activity. The photoinduced electron transfer (PeT)-based fluorophore incorporates into the mycobacterial cell wall, producing detectable fluorescence within 15 minutes and thus, highlighting its suitability for rapid, point-of-care TB detection in low-resource settings.

MeSH terms

  • Mycobacterium tuberculosis
  • Fluorophore
  • Tuberculosis
  • Conjugate
  • Fluorescence
  • Chemistry
  • Combinatorial chemistry
  • Nanotechnology
  • Microbiology