A dual-function probe for inhibition and rapid detection of <i>Mycobacterium tuberculosis</i>
Sonali Chhabra, Raman Parkesh
Chemical Communications · 2025-01
Abstract
by targeting the DprE1 enzyme, while also exhibiting antimicrobial activity. The photoinduced electron transfer (PeT)-based fluorophore incorporates into the mycobacterial cell wall, producing detectable fluorescence within 15 minutes and thus, highlighting its suitability for rapid, point-of-care TB detection in low-resource settings.
MeSH terms
- Mycobacterium tuberculosis
- Fluorophore
- Tuberculosis
- Conjugate
- Fluorescence
- Chemistry
- Combinatorial chemistry
- Nanotechnology
- Microbiology