Challenges in developing new tuberculosis vaccines
Gabriela Sadigurschi, Maria Kuschni, Ewerton Alves Portela dos Santos, Bruno Bezerra da Silva, Celia Marques, Clarice Monteiro Vianna, Danieli Lazarini de Barros, Ernani Paulino do Lago, et al. (10 authors)
Abstract
Introduction: Tuberculosis (TB) is a preventable and curable disease caused by Mycobacterium tuberculosis (M.tuberculosis).In 2022, TB was the second leading cause of death worldwide due to a single infectious agent, after COVID-19.Brazil is among the 30 countries with the highest TB burden.The Bacillus Calmette-Gurin (BCG) vaccine is the only licensed vaccine for TB.While it provides protection against severe childhood TB, its effectiveness in preventing adult pulmonary TB is limited, underscoring the need for a more effective vaccine.Objectives: This study aims to explore the challenges in developing new TB vaccines.
MeSH terms
- Tuberculosis
- Virology
- Computer science
- Medicine