Pulmonary Tuberculosis in a Child with Noonan Syndrome (A Clinical Case)

The article presents a clinical observation of a rare case of concurrent tuberculosis and congenital disease (Noonan syndrome) in a 14-year-old child. Noonan syndrome manifested by multiple stigmas of dysembryogenesis, heart defect, delayed physical and sexual development, cryptorchidism, and keel-shaped chest deformity. At the age of 6 years, the boy was exposed to two relatives suffering from tuberculosis with a positive result of the sputum test, he received no preventive treatment. He was diagnosed with tuberculosis at the age of 14 years when infiltrative changes in the lung were detected by X-ray. During diagnosis, it is worth highlighting that the result of Interferon-Gamma Release Assay (IGRA – T-SPOT TB) was positive, while the result of the TRA test was negative. No bacterial excretion was detected during the entire period of the disease, tuberculosis had no specific course and was successfully cured.