IL-27 signaling limits the diversity of antigen-specific T cells and interferes with protection induced by BCG vaccination
Ashley M. Divens, Kenneth J. Ryan, A Sette, Cecilia S. Lindestam Arlehamn, Cory M. Robinson
Tuberculosis · 2025-04
Abstract
mice. A principal component analysis suggested a more consistent multifunctional cytokine response was associated IL-27Rα KO T cells. These findings enhance our understanding of IL-27 during neonatal vaccination and development of protective immunity.
MeSH terms
- Vaccination
- Antigen
- Immunology
- Tuberculosis
- BCG vaccine
- Diversity (politics)
- Virology
- Biology