World TB Day 2025 Theme “Yes! We Can End TB: Commit, Invest, Deliver” can be made a reality through concerted global efforts to advance diagnosis, treatment and research of tuberculosis infection and disease

World TB Day 2025 Theme "Yes!We Can End TB: Commit, Invest, Deliver " can be made a reality through concerted global effort s to advance diagnosis, treatment and research of tuberculosis infection and disease World TB Day is observed annually on March 24th to raise awareness of tuberculosis (TB), a preventable and treatable disease [ 1 ].However, despite being treatable for over 65 years, there are approximately 10.8 million new TB cases annually, predominantly in low-and middle-income countries.Drug-resistant and multidrug-resistant (MDR)-TB significantly contributes to deaths, impacting an estimated 40 0,0 0 0 individuals each year.TB-HIV coinfection remains a major concern, with an estimated 660,0 0 0 individuals affected by the dual infection.TB is an important cause of maternal, child and adolescent morbidity and mortality.After three years during which COVID-19 was the predominant cause of death from infectious diseases, TB regained this position in 2023, causing an estimated 1.25 million deaths.The World Health Organization (WHO) and STOP TB Partnership have designated "Yes!We Can End TB: Commit, Invest, Deliver" as the theme for the 2025 World TB Day [ 2 ]. "Commit" refers to the pledge of heads of states and governments to eradicate TB disease at the 2023 United Nations High-Level Meeting (HLM).However, this commitment will remain unachievable without concrete actions, funding, national strategies, and policies."Invest" refers to adequately financing TB responses through various investments and funding channels.The recent decision by the United States (US) government to terminate activities of US Agency for International Development (USAID) has shocked the global community and is viewed as a significant barrier to achieving the United Nations General Assembly (UNGA) and WHO End TB targets [ 3 ].This calls for a structured action of generating new funding sources from the national governments and the private sectors [ 3 ]."Deliver" refers to transforming commitments into tangible benefits for people affected by TB, including scaling up evidence-based interventions, active case finding, early diagnosis, preventive treatment, and quality care for drug-resistant TB.This special IJID themed section for World TB Day includes latest reviews covering important aspects of TB as regards its elimination -preventive therapy for MDR patients [ 4 ], issues relating to TB in young people [ 5 , 6 ], HIV-TB coinfection [ 7 ], host directed therapy (HDT) focusing on the treatment of TB with diabetes comorbidity [ 8 ], and TB infection (TBI) testing [ 9 ].Recent findings indicate that nearly 50% of TB cases do not present with or report symptoms, resulting in undiagnosed and potentially infectious