Review 2: "Immunopeptidomics Informs Discovery and Delivery of Mycobacterium Tuberculosis MHC-II Antigens for Vaccine Design"

Review: This study presents a well-executed investigation into Mtb antigen presentation via MHC-II, with direct implications for TB vaccine design.By employing immunopeptidomics, the authors identify a subset of Mtb peptides presented on MHC-II by human dendritic cells, a crucial step in defining vaccine-relevant targets.The strength of this approach lies in its use of primary human cells, ensuring translational relevance, and its