Signs of Electrophysiological Myocardial Remodeling in Respiratory Tuberculosis Patients according to Daily ECG Monitoring Data

The objective: to optimize diagnostics of cardiovascular disorders in respiratory tuberculosis patients during anti-tuberculosis therapy. Subjects and Methods. A total of 93 patients with pulmonary tuberculosis without concomitant cardiovascular diseases (CVD) were examined. Daily electrocardiogram monitoring was performed for at least 24 hours using 3 leads. The parameters of the myocardial repolarization were analyzed. The results of the study were processed using MS EXCEL 2016 for Windows and STATISTICA 10 by nonparametric methods. Results. Various signs of electrophysiological remodeling (ER) combining with each other were identified. Most often, these changes were expressed in hyperadaptation of QT to heart rate and decrease in dQT and Tp-e values. Increased QTcFmin, dQT, Tp-e were rare. Elevated values of the iCEB index were more often detected in patients with a higher average daily QT duration. No statistically significant differences in ER indices were found between the groups of patients with limited and widespread tuberculosis. Patients with respiratory tuberculosis should have their QT dynamics analyzed and signs of ER should not be limited to QT interval testing alone. QT changes do not depend on the degree of pulmonary tuberculosis dissemination.