Unraveling the role of IL-17A variants in pulmonary tuberculosis: Insights from a case-control study

The present study aimed to investigate the association between certain interleukin-17 A ( IL-17 A ) polymorphisms, specifically rs2275913 and rs8193036, and the susceptibility to pulmonary tuberculosis (PTB). Considering the function of IL-17 A in regulating immunological responses, especially regarding bacterial infections, we sought to determine if variations in the IL-17 A gene effect on PTB in the examined group. We performed a case-control study with 100 individuals who were confirmed to have PTB and 100 control subjects. Genotyping for the IL-17 A SNPs rs2275913 and rs8193036 was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and Tetra-primer Amplification Refractory Mutation System (Tetra-ARMS PCR) methodologies. A statistical analysis encompassing odds ratios (OR) and 95 % confidence intervals (CI) was conducted to assess the association between the polymorphisms and the risk of PTB. Our data indicated a significant connection between the rs2275913 polymorphism and elevated susceptibility to PTB (OR = 1.69, 95 % CI: 1.09–2.61; p = 0.031). Also, a significant association between the rs8193036 polymorphism and increased susceptibility to PTB (OR = 2.18, 95 % CI: 1.46–3.27; p < 0.001). The IL-17 A polymorphisms rs2275913 and rs8193036 strongly correlate with increased susceptibility to PTB, according to this study. This suggests a potential genetic risk factor in the progression of the disease. • This study investigates the association between IL-17 A gene variants and susceptibility to pulmonary tuberculosis (TB), providing insights into potential genetic factors influencing disease outcomes. • A case-control approach was employed, analyzing a well-defined cohort of pulmonary TB patients and matched healthy controls to ensure reliable comparisons regarding IL-17 A variants. • The research closely examined specific single nucleotide polymorphisms (SNPs) in the IL-17 A gene, evaluating their frequency and distribution among both TB patients and controls. • The study identifies significant associations between certain IL-17 A variants and increased risk of developing pulmonary TB.