POTENT CYTOTOXIC AND ANTIOXIDANT CAPACITIES OF NOVEL ISONIAZID GLEANED COPPER AND COBALT COMPLEXES

The hexacoordinated mixed ligand Cu(II) and Co(II) complexes have been synthesized from the condensation reactions between isoniazid and salicylaldehyde. The synthesized ligand and its metal complexes were characterized by spectral techniques such as elemental analysis, molar conductance, magnetic susceptibility, ultraviolet-visible spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FTIR), 1H and 13C nuclear magnetic resonance spectroscopy (NMR), gas chromatography mass spectrometry (GC-MS) and high resolution mass spectrometry (HRMS). The high molar conductance of the complexes showed their electrolytic nature. The octahedral geometry has been proposed for the complexes. The stretching vibration of imine group was observed in FTIR of the ligand and its shifts to lower frequency in complexes confirmed the formation of metal complexes. The electronic spectrum of complexes exhibited the charge transfer, d-d transitions in accordance with their proposed geometry. The mass spectral data also proved the structure of complexes as octahedral. DPPH antioxidant studies revealed copper complex exhibits most efficient radical scavenger. The compounds have been investigated for their cytotoxicity activity on HeLA Cervical cancer cells. Copper complex (40μg/ml ±2μg/ml) showed promising cytotoxicity in the tumor cell line.