A STUDY TO DETERMINE VITAMIN-D DEFICIENCY IN TUBERCULOSIS PATIENTS AT A TERTIARY CARE HOSPITAL IN NORTHERN INDIA

Background: Tuberculosis (TB), caused by Mycobacterium tuberculosis, is a global health challenge, particularly in India. Vitamin-D, known for its immunomodulatory effects, has been implicated in TB susceptibility and progression. Objective: To evaluate the prevalence of Vitamin-D deciency in TB patients and its association with clinical parameters. Methodology: This cross-sectional observational study included 72 TB patients (pulmonary and extrapulmonary) and 72 age- and sex-matched controls. Serum Vitamin-D levels were measured using the EnzymeLinked Fluorescent Assay (ELFA). Results: TB patients had signicantly lower mean Vitamin-D levels (23.1 ± 7.75 ng/mL) compared to controls (28.2 ± 8.2 ng/mL, p < 0.001). Vitamin-D deciency (< 20 ng/mL) was more prevalent in TB patients (52.8%) than controls (26.4%, p = 0.001). Pulmonary and extrapulmonary TB patients exhibited similar Vitamin-D proles, with no statistically signicant differences. Conclusion: The ndings of this study highlight a signicant prevalence of Vitamin-D deciency among tuberculosis patients, emphasizing its association with more severe clinical manifestations. Strategies integrating Vitamin-D supplementation into TB treatment protocols are recommended.