BACTERIAL AND FUNGAL INFECTIONS IN PULMONARY TUBERCULOSIS PATIENTS AND THE DRUG SENSITIVITY TEST PATTERNS.

Background: Other microbial infections in pulmonary tuberculosis (TB) patients pose significant challenges, complicating treatment outcomes and potentially increasing mortality rates. This study aims to characterize the bacterial and fungal infections profiles in pulmonary TB patients. Materials and Methods: A retrospective cross-sectional analysis was conducted at Adam Malik Hospital in Medan, Indonesia, from June 2020 to May 2022, involving inpatients diagnosed with drug-sensitive or drug-resistant TB. The data was analyzed from total sampling subjects based on medical records. Results: as the most common microbes. %<Microbial growth patterns were significantly different between DS-TB and DR-TB patients, with 38.8% (n=31) of DS-TB patients displaying mixed bacterial and fungal growth, in contrast to only 15.6% (n=7) of DR-TB patients. There were no significant differences in antibiotic resistance; however, antifungal sensitivity testing revealed a significant difference in response between DS-TB and DR-TB patients, particularly to Flucytosine, Fluconazole, and Micafungin. Conclusions: being the most prevalent. The antifungal sensitivity testing suggesting a need for personalized antifungal treatment strategies between DS-TB and DR-TB patients.